دورية أكاديمية
Meta-analysis of experimental data concerning antimicrobial resistance gene transfer rates during conjugation.
| العنوان: | Meta-analysis of experimental data concerning antimicrobial resistance gene transfer rates during conjugation. |
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| المؤلفون: | Hunter PR; School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, United Kingdom. paul.hunter@uea.ac.uk, Wilkinson DC, Catling LA, Barker GC |
| المصدر: | Applied and environmental microbiology [Appl Environ Microbiol] 2008 Oct; Vol. 74 (19), pp. 6085-90. Date of Electronic Publication: 2008 Aug 15. |
| نوع المنشور: | Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 7605801 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5336 (Electronic) Linking ISSN: 00992240 NLM ISO Abbreviation: Appl Environ Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, American Society for Microbiology. |
| مواضيع طبية MeSH: | Conjugation, Genetic* , Drug Resistance, Bacterial*, Bacteria/*drug effects , Bacteria/*genetics, Humans |
| مستخلص: | This paper presents the results of a meta-analysis of published transfer rates of antimicrobial resistance genes. A total of 34 papers were identified, of which 28 contained rates estimated in relation to either donor or recipient bacterial counts. The published rates ranged from 10(-2) to 10(-9). Generalized linear modeling was conducted to identify the factors influencing this variation. Highly significant associations between transfer frequency and both the donor (P = 1.2 x 10(-4)) and recipient (P = 1.0 x 10(-5)) genera were found. Also significant was whether the donor and recipient strains were of the same genus (P = 0.023) and the nature of the genetic element (P = 0.0019). The type of experiment, in vivo or in vitro, approached statistical significance (P = 0.12). Parameter estimates from a general linear model were used to estimate the probability of transfer of antimicrobial resistance genes to potential pathogens in the intestine following oral ingestion. The mean logarithms of these probabilities are in the range of [-7.0, -3.1]. These probability distributions are suitable for use in the quantitative assessment of the risk of transfer of antimicrobial resistance genes to the intestinal flora of humans and animals. |
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| معلومات مُعتمدة: | United Kingdom Biotechnology and Biological Sciences Research Council |
| تواريخ الأحداث: | Date Created: 20080819 Date Completed: 20081023 Latest Revision: 20211020 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC2565951 |
| DOI: | 10.1128/AEM.01036-08 |
| PMID: | 18708517 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1098-5336 |
|---|---|
| DOI: | 10.1128/AEM.01036-08 |