دورية أكاديمية
أعرض في EDS

Carriage of Leptospira interrogans among domestic rats from an urban setting highly endemic for leptospirosis in Brazil.

التفاصيل البيبلوغرافية
العنوان: Carriage of Leptospira interrogans among domestic rats from an urban setting highly endemic for leptospirosis in Brazil.
المؤلفون: de Faria MT; Gonçalo Moniz Research Centre, Oswaldo Cruz Foundation, Ministry of Health, Salvador, Brazil. tucun@cpatu.embrapa.br, Calderwood MS, Athanazio DA, McBride AJ, Hartskeerl RA, Pereira MM, Ko AI, Reis MG
المصدر: Acta tropica [Acta Trop] 2008 Oct; Vol. 108 (1), pp. 1-5. Date of Electronic Publication: 2008 Jul 31.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6254 (Electronic) Linking ISSN: 0001706X NLM ISO Abbreviation: Acta Trop Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier
Original Publication: Basel.
مواضيع طبية MeSH: Disease Reservoirs*, Carrier State/*veterinary , Leptospira interrogans/*isolation & purification , Leptospirosis/*veterinary , Rats/*microbiology, Agglutination Tests ; Animals ; Bacterial Typing Techniques ; Blood/microbiology ; Brazil ; Carrier State/epidemiology ; Carrier State/microbiology ; Didelphis/microbiology ; Kidney/microbiology ; Leptospira interrogans/classification ; Leptospirosis/epidemiology ; Leptospirosis/transmission ; Serotyping ; Urban Health ; Urine/microbiology
مستخلص: A survey was conducted to identify reservoirs for urban leptospirosis in the city of Salvador, Brazil. Sampling protocols were performed in the vicinity of households of severe leptospirosis cases identified during active hospital-based surveillance. Among a total of 142 captured Rattus norvegicus (Norwegian brown rat), 80.3% had a positive culture isolate from urine or kidney specimens and 68.1% had a positive serum sample by microscopic agglutination test (MAT) titre of > or = 1:100. Monoclonal antibody-based typing of isolates identified that the agent carried by rats was Leptospira interrogans serovar Copenhageni, which was the same serovar isolated from patients during hospital-based surveillance. Leptospira spp. were not isolated from 8 captured Didelphis marsupialis (Opossum), while 5/7 had a positive MAT titre against a saprophytic serogroup. R. rattus were not captured during the survey. The study findings indicate that the brown rat is a major rodent reservoir for leptospirosis in this urban setting. Furthermore, the high carriage rates of L. interrogans serovar Copenhageni in captured rats suggest that there is a significant degree of environmental contamination with this agent in the household environment of high risk areas, which in turn is a cause of transmission during urban epidemics.
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معلومات مُعتمدة: D43 TW000919 United States TW FIC NIH HHS; D43 TW000919-07 United States TW FIC NIH HHS; D43 TW00919 United States TW FIC NIH HHS; R01 AI052473 United States AI NIAID NIH HHS; R01 AI052473-05 United States AI NIAID NIH HHS
تواريخ الأحداث: Date Created: 20080830 Date Completed: 20081211 Latest Revision: 20220409
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC2596941
DOI: 10.1016/j.actatropica.2008.07.005
PMID: 18721789
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-6254
DOI:10.1016/j.actatropica.2008.07.005