دورية أكاديمية
أعرض في EDS

Interaction of interleukin-6 and estrogen receptor gene polymorphisms on bone mass accrual in Chinese adolescent girls.

التفاصيل البيبلوغرافية
العنوان: Interaction of interleukin-6 and estrogen receptor gene polymorphisms on bone mass accrual in Chinese adolescent girls.
المؤلفون: Xing L; Department of Nutrition, School of Public Health, Sun Yat-sen University, 74 Zhongshan Rd 2, Guangzhou, China., He GP, Chen YM, Su YX
المصدر: Journal of bone and mineral metabolism [J Bone Miner Metab] 2008; Vol. 26 (5), pp. 493-8. Date of Electronic Publication: 2008 Aug 30.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Japanese Society of Bone and Mineral Metabolism Country of Publication: Japan NLM ID: 9436705 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0914-8779 (Print) Linking ISSN: 09148779 NLM ISO Abbreviation: J Bone Miner Metab Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Tokyo : Japanese Society of Bone and Mineral Metabolism, [1988-
مواضيع طبية MeSH: Polymorphism, Genetic*, Bone Density/*genetics , Estrogen Receptor alpha/*genetics , Interleukin-6/*genetics, Adolescent ; Child ; China ; Estrogen Receptor alpha/metabolism ; Female ; Genotype ; Humans ; Interleukin-6/metabolism ; Surveys and Questionnaires
مستخلص: We assessed the main and interaction effects of interleukin-6 and estrogen receptor gene polymorphisms on bone mass accrual in Chinese adolescent girls. A total of 228 premenarche Chinese girls (9-11.5 years old) were recruited for a 2-year follow-up study. Bone mineral density (BMD) at the total body, lumbar spine (L1-L4), and total left hip were measured by dual-energy X-ray absorptiometry at baseline and follow-up. The -174G/C and -634C/G polymorphism of IL-6 gene, and PvuII and XbaI polymorphisms of the estrogen receptor (ER)-alpha gene, were determined. The -634C/G polymorphism of the IL-6 gene and PvuII polymorphism of ER-alpha gene were significantly associated with bone mass accrual after adjusting the potential confounding factors. Girls with pp genotype of ER-alpha gene had greater percentage accrual in BMD of total body (P = 0.010) and femoral intertrochanter (P = 0.038) than their PP and Pp counterparts. Girls with CC genotype of IL-6 -634G/C gene had higher percentage accrual in BMD of total body (P = 0.032) and femoral trochanter (P = 0.048) than their CG + GG counterparts. Significant interaction effects of IL-6 -634C/G polymorphism and ER-alpha PvuII polymorphism were observed on percentage change in BMD of total left hip (P = 0.009) and femoral intertrochanter (P = 0.007). The genotype CC (IL-6 -634C/G) x pp (ER-alpha PvuII) was associated with greater BMD accrual than other genotype combination in Chinese adolescent girls. We found that the IL-6 -634C/G and ER-alpha PvuII polymorphism were significantly associated with BMD accrual and that they have an interactional effect on BMD accrual in Chinese adolescent girls.
References: J Endocrinol. 2000 Nov;167(2):305-13. (PMID: 11054645)
J Clin Invest. 1992 Mar;89(3):883-91. (PMID: 1541679)
J Endocrinol. 2003 May;177(2):147-96. (PMID: 12740006)
J Bone Miner Res. 1998 Apr;13(4):695-705. (PMID: 9556070)
J Bone Miner Res. 1996 Aug;11(8):1043-51. (PMID: 8854239)
Endocrinology. 1995 Sep;136(9):4056-67. (PMID: 7649114)
J Bone Miner Metab. 2005;23(4):323-8. (PMID: 15981030)
J Hum Genet. 2001;46(5):267-72. (PMID: 11355017)
J Clin Endocrinol Metab. 1998 Mar;83(3):939-44. (PMID: 9506753)
J Bone Miner Res. 1999 Apr;14(4):633-43. (PMID: 10234586)
Diabetologia. 2002 Mar;45(3):453-4. (PMID: 11914754)
Eur J Endocrinol. 1995 Sep;133(3):265-71. (PMID: 7581940)
J Bone Miner Res. 1996 Mar;11(3):306-11. (PMID: 8852941)
J Bone Miner Metab. 2003;21(1):34-42. (PMID: 12491092)
J Bone Miner Res. 1998 May;13(5):777-85. (PMID: 9610741)
Hum Mol Genet. 2000 Aug 12;9(13):2043-50. (PMID: 10942433)
J Bone Miner Res. 2000 Aug;15(8):1545-54. (PMID: 10934653)
J Clin Endocrinol Metab. 2003 Jul;88(7):3372-8. (PMID: 12843190)
Bone. 2002 Jul;31(1):43-50. (PMID: 12110411)
Med Sci Sports Exerc. 1997 Oct;29(10):1344-9. (PMID: 9346166)
Chin Med J (Engl). 1999 Sep;112(9):832-5. (PMID: 11717956)
Pharmacogenetics. 2001 Nov;11(8):699-701. (PMID: 11692078)
N Engl J Med. 1995 Feb 2;332(5):305-11. (PMID: 7816067)
Mol Genet Metab. 2006 Jan;87(1):80-7. (PMID: 16243557)
J Rheumatol. 2005 Dec;32(12):2400-4. (PMID: 16331771)
Mol Endocrinol. 1999 Jun;13(6):819-28. (PMID: 10379881)
J Bone Miner Res. 2000 Nov;15(11):2095-122. (PMID: 11092392)
J Bone Miner Res. 2001 Feb;16(2):379-85. (PMID: 11204438)
Arthritis Rheum. 2001 Jan;44(1):196-201. (PMID: 11212160)
J Bone Miner Res. 2000 Feb;15(2):315-21. (PMID: 10703934)
Ann N Y Acad Sci. 1998 May 1;840:194-204. (PMID: 9629251)
J Bone Miner Res. 2002 Mar;17(3):384-93. (PMID: 11874231)
J Hum Genet. 2005;50(9):477-482. (PMID: 16160748)
المشرفين على المادة: 0 (Estrogen Receptor alpha)
0 (Interleukin-6)
تواريخ الأحداث: Date Created: 20080902 Date Completed: 20081006 Latest Revision: 20211020
رمز التحديث: 20240513
DOI: 10.1007/s00774-007-0844-y
PMID: 18758908
قاعدة البيانات: MEDLINE
الوصف
تدمد:0914-8779
DOI:10.1007/s00774-007-0844-y