دورية أكاديمية
[Efficacy of therapy of different variants of anaplastic large T-cell lymphomas].
| العنوان: | [Efficacy of therapy of different variants of anaplastic large T-cell lymphomas]. |
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| المؤلفون: | Vinogradova IuE, Lutsenko IN, Kaplanskaia IB, Vorob'ev IA, Samoĭlova RS, Gorgidze LA, Ryzhikova NA, Valiev TT, Giliazitdinova EA, Dzhulakian UL, Egorova EK, Zvonkov EE, Krasil'nikova BB, Magomedova AU, Margolin OV, Mar'in DS, Kremenetskaia AM, Kravchenko SK, Vorob'ev AI |
| المصدر: | Terapevticheskii arkhiv [Ter Arkh] 2008; Vol. 80 (7), pp. 33-7. |
| نوع المنشور: | Comparative Study; English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: ZAO 'Konsilium Medikum Country of Publication: Russia (Federation) NLM ID: 2984818R Publication Model: Print Cited Medium: Print ISSN: 0040-3660 (Print) Linking ISSN: 00403660 NLM ISO Abbreviation: Ter Arkh Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2018- > : Moskva : ZAO 'Konsilium Medikum' Original Publication: Moskva : Izdatelʹstvo Medit︠s︡ina |
| مواضيع طبية MeSH: | Antineoplastic Combined Chemotherapy Protocols/*therapeutic use , Lymphoma, Large-Cell, Anaplastic/*drug therapy, Adolescent ; Adult ; Asparaginase/therapeutic use ; Bleomycin/therapeutic use ; Cyclophosphamide/therapeutic use ; Daunorubicin/therapeutic use ; Dose-Response Relationship, Drug ; Doxorubicin/therapeutic use ; Etoposide/therapeutic use ; Female ; Follow-Up Studies ; Humans ; Leucovorin/therapeutic use ; Lymphoma, Large-Cell, Anaplastic/diagnosis ; Male ; Methotrexate/therapeutic use ; Middle Aged ; Prednisone/therapeutic use ; Procarbazine/therapeutic use ; Remission Induction/methods ; Treatment Outcome ; Vincristine/therapeutic use |
| مستخلص: | Aim: To compare efficacy of NHL-BFM-90 and CHOP-like courses in the treatment of anaplastic large cell lymphoma (ALCL). Material and Methods: Twenty-two patients with ALCL participated in the study. The diagnosis was made basing on the findings of clinical, device, morphological, immunohistochemical and molecular-genetic examinations with application of a panel of monoclonal antibodies to CD30, ALK, CD3, CD4, CDS, CD7, CD34, CD15, CD68, CD20, CD45RO, CD45RA, Ki-67. 14 cases of 22 were negative by kinase of anaplastic lymphocytes (ALK-) and 8 were positive (ALK+). Mean age of ALK-ALCL patients was 39.6 +/- 4.1 years, of ALK+ALCL patients - 23.4 +/- 2.6 years. 14 patients were treated by the protocol NHL-BFM-90, 8 were initially treated with other schemes (CHOP, MACOP-B, BEACOPP and others). All 14 patients treated according to NHL-BFM-90 had ALCL stages III-IV with B-symptoms. 12 patients who completed treatment by the above protocol achieved complete remission after the forth course, 2 patients failed the treatment. Of 8 ALCL patients treated initially according to other schemes, a complete remission was achieved in 4 patients (2 had stage II). One of 4 patients with remission had recurrence. Four patients who had failed to achieve complete remission died of the disease progression. Conclusion: ALCL occurs more frequently in young and middle-aged patients. The disease has an aggressive course with rapid generalization. For such processes it is more preferable to use a modified protocol NHL-BFM-90. |
| المشرفين على المادة: | 11056-06-7 (Bleomycin) 35S93Y190K (Procarbazine) 5J49Q6B70F (Vincristine) 6PLQ3CP4P3 (Etoposide) 80168379AG (Doxorubicin) 8N3DW7272P (Cyclophosphamide) EC 3.5.1.1 (Asparaginase) Q573I9DVLP (Leucovorin) VB0R961HZT (Prednisone) YL5FZ2Y5U1 (Methotrexate) ZS7284E0ZP (Daunorubicin) |
| SCR Protocol: | BEACOPP protocol; CHOP protocol; MACOP-B protocol; PVDA protocol |
| تواريخ الأحداث: | Date Created: 20080904 Date Completed: 20081104 Latest Revision: 20151119 |
| رمز التحديث: | 20240628 |
| PMID: | 18763592 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0040-3660 |
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