دورية أكاديمية
أعرض في EDS

Genetic diversity in the yellow head nidovirus complex.

التفاصيل البيبلوغرافية
العنوان: Genetic diversity in the yellow head nidovirus complex.
المؤلفون: Wijegoonawardane PK; CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St. Lucia, Queensland 4067, Australia., Cowley JA, Phan T, Hodgson RA, Nielsen L, Kiatpathomchai W, Walker PJ
المصدر: Virology [Virology] 2008 Oct 25; Vol. 380 (2), pp. 213-25. Date of Electronic Publication: 2008 Sep 02.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0110674 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0341 (Electronic) Linking ISSN: 00426822 NLM ISO Abbreviation: Virology Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, Academic Press.
مواضيع طبية MeSH: Genetic Variation*, Penaeidae/*virology , RNA Virus Infections/*virology , Roniviridae/*classification , Roniviridae/*isolation & purification, 3' Untranslated Regions ; Amino Acid Sequence ; Animals ; Australasia ; Base Sequence ; DNA, Intergenic ; Genes, Viral ; Genotype ; Molecular Sequence Data ; Nucleic Acid Conformation ; Open Reading Frames ; Phylogeny ; RNA, Viral/genetics ; Roniviridae/genetics ; Sequence Alignment ; Sequence Analysis, DNA ; Sequence Homology
مستخلص: Penaeus monodon shrimp collected from across the Indo-Pacific region during 1997-2004 were screened for the presence of yellow head-related viruses. Phylogenetic analyses of amplified ORF1b gene segments identified at least six distinct genetic lineages (genotypes). Genotype 1 (YHV) was detected only in shrimp with yellow head disease. Genotype 2 (GAV) was detected in diseased shrimp with the less severe condition described as mid-crop mortality syndrome and in healthy shrimp from Australia, Thailand and Vietnam. Other genotypes occurred commonly in healthy shrimp. Sequence comparisons of structural protein genes (ORF2 and ORF3), intergenic regions (IGRs) and the long 3'-UTR supported the delineation of genotypes and identified both conserved and variant structural features. In putative transcription regulating sequences (TRSs) encompassing the sub-genomic mRNA 5'-termini, a core motif (5'-GUCAAUUACAAC-3') is absolutely conserved. A small (83 nt) open reading frame (ORF4) in the 3'-UTR of GAV is variously truncated in all other genotypes and a TRS-like element preceding ORF4 is invariably corrupted by a A>G/U substitution in the central core motif (5'-UU(G/U)CAAC-3'). The data support previous evidence that ORF4 is a non-functional gene under construction or deconstruction. The 3'-UTRs also contain predicted 3'-terminal hairpin-loop structures that are preserved in all genotypes by compensatory nucleotide substitutions, suggesting a role in polymerase recognition for minus-strand RNA synthesis.
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المشرفين على المادة: 0 (3' Untranslated Regions)
0 (DNA, Intergenic)
0 (RNA, Viral)
تواريخ الأحداث: Date Created: 20080905 Date Completed: 20081106 Latest Revision: 20211020
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7103379
DOI: 10.1016/j.virol.2008.07.005
PMID: 18768192
قاعدة البيانات: MEDLINE
الوصف
تدمد:1096-0341
DOI:10.1016/j.virol.2008.07.005