دورية أكاديمية
Characteristics of patients with liver disease intravenously exposed to diethylene glycol in China 2006.
| العنوان: | Characteristics of patients with liver disease intravenously exposed to diethylene glycol in China 2006. |
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| المؤلفون: | Peng XM; Hospital for Liver Disease, Sun Yat-Sen University, Guangzhou, China., Huang MX, Gu L, Lin BL, Chen GH |
| المصدر: | Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2009 Feb; Vol. 47 (2), pp. 124-31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101241654 Publication Model: Print Cited Medium: Internet ISSN: 1556-9519 (Electronic) Linking ISSN: 15563650 NLM ISO Abbreviation: Clin Toxicol (Phila) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Philadelphia, PA : Taylor & Francis, c2005- |
| مواضيع طبية MeSH: | Drug Contamination*, Acute Kidney Injury/*chemically induced , Benzopyrans/*administration & dosage , Cholagogues and Choleretics/*administration & dosage , Ethylene Glycols/*poisoning , Liver Diseases/*drug therapy, Adult ; Case-Control Studies ; China ; Drug Compounding ; Ethylene Glycols/administration & dosage ; Female ; Hepatorenal Syndrome/etiology ; Humans ; Injections, Intravenous ; Kidney Function Tests ; Liver Diseases/complications ; Liver Function Tests ; Male ; Middle Aged ; Risk Factors ; Severity of Illness Index ; Time Factors |
| مستخلص: | Background: Diethylene glycol (DEG) poisoning is life-threatening. The clinical characteristics of patients with liver disease exposed to intravenous DEG have not been clarified. Methods: Sixty-four patients with moderate to severe liver disease exposed to DEG in China in 2006 were investigated. Results: The daily exposure total dose was 3-6 mL of a 30% (v/v) mixture. Acute renal failure (ARF), the predominant clinical manifestation, occurred in 23.4% (15/64) of these patients. The average time to onset was 6.53 +/- 3.48 days after exposure to DEG. ARF could be differentiated from the hepatorenal syndrome that usually occurs in patients with severe liver disease. The occurrence of ARF was significantly related to pre-existing renal function abnormality, and was not influenced by the allele distribution of DEG-metabolizing enzyme. The liver function profiles did not significantly change after DEG exposure. Conclusions: ARF was the main clinical manifestation in this intravenous DEG poisoning accident. The influence of underlying liver disease on DEG poisoning or that of DEG exposure on liver disease has many implications. |
| المشرفين على المادة: | 0 (Benzopyrans) 0 (Cholagogues and Choleretics) 0 (Ethylene Glycols) 61BR964293 (diethylene glycol) M5864MH5CT (armillarisin A) |
| تواريخ الأحداث: | Date Created: 20080917 Date Completed: 20090326 Latest Revision: 20121115 |
| رمز التحديث: | 20240513 |
| DOI: | 10.1080/15563650802245489 |
| PMID: | 18792827 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1556-9519 |
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| DOI: | 10.1080/15563650802245489 |