دورية أكاديمية
أعرض في EDS

[Accelerated partial breast irradiation using interstitial high dose rate brachytherapy: preliminary clinical and dosimetric results after 61 patients].

التفاصيل البيبلوغرافية
العنوان: [Accelerated partial breast irradiation using interstitial high dose rate brachytherapy: preliminary clinical and dosimetric results after 61 patients].
عنوان ترانسليتريتد: Irradiation insterstitielle partielle et accélérée du sein de haut débit de dose: résultats préliminaires cliniques et dosimétriques sur 61 patientes.
المؤلفون: Hannoun-Levi JM; Département de radiothérapie, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice cedex, France. jean-michel.hannoun-levi@nice.fnclcc.fr, Ferré M, Raoust I, Lallement M, Flipo B, Ettore F, Marcié S
المصدر: Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique [Cancer Radiother] 2008 Nov; Vol. 12 (6-7), pp. 532-40. Date of Electronic Publication: 2008 Oct 05.
نوع المنشور: English Abstract; Journal Article
اللغة: French
بيانات الدورية: Publisher: Elsevier Country of Publication: France NLM ID: 9711272 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1278-3218 (Print) Linking ISSN: 12783218 NLM ISO Abbreviation: Cancer Radiother Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Paris : Elsevier, c1997-
مواضيع طبية MeSH: Brachytherapy/*methods , Breast Neoplasms/*radiotherapy, Aged ; Aged, 80 and over ; Brachytherapy/adverse effects ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Combined Modality Therapy ; Female ; Humans ; Mastectomy, Segmental ; Neoplasm Staging ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods ; Skin/pathology ; Skin/radiation effects
مستخلص: Purpose: Among all the accelerated and partial breast irradiation (APBI) techniques, low then high dose rate, interstitial brachytherapy (HDIB) was the first to be used in this field. This study presents the preliminary clinical and dosimetric results of the APBI using HDIB, performed in Antoine Lacassagne Cancer Center of Nice.
Patients and Methods: From June 2004 to March 2008, 61 patients (37 primary tumors and 24 second conservative treatments after local recurrence) presenting with T1-2 pN0 non-lobular invasive breast carcinoma, underwent lumpectomy with sentinel lymph node dissection and intraoperative tube placement for HDIB. Dose distribution analysis, using dose-volume histograms, was achieved based on a postoperative CT scan. A comparative dosimetric study was performed between optimized (O) and non-optimized (NO) dose distribution. Then, based on conformal index calculation, a novel index was proposed taking into account not only the conformity but also the homogeneity of HDIB implant. An analysis of dose gradient impact on HDIB biological equivalence dose was also conducted. Statistical analysis used T test confirmed by Wilcoxon test for cohort including less than 30 patients.
Results: The comparative dosimetric analysis between O and NO dose distributions shown that conformity indexes (conformal index, conformal number, and D90%) were significantly increased after optimization. Improving conformity leads to increasing hyperdosage volumes (V150% and V200%). A new index named conformity and homogeneity index (CHI) including V150% values, modified the conformal index. A total dose of 34 Gy, delivered through HDIB in 10 fractions over five days was biologically equivalent to 41.93 Gy assuming alpha/beta = 4 Gy and 75.76 Gy if the dose gradient was considered in the calculation.
Conclusions: HDIB is considered as one of the best IPAS technique. HDIB allows dose distribution optimization, skin spearing and accurate clinical target volume definition. Furthermore, HDIB dose gradient could play a key role for breast cancer local control.
تواريخ الأحداث: Date Created: 20081007 Date Completed: 20081231 Latest Revision: 20081105
رمز التحديث: 20240628
DOI: 10.1016/j.canrad.2008.09.008
PMID: 18835737
قاعدة البيانات: MEDLINE
الوصف
تدمد:1278-3218
DOI:10.1016/j.canrad.2008.09.008