دورية أكاديمية
[Studies on pharmacokinetics of artemether patch in mice].
| العنوان: | [Studies on pharmacokinetics of artemether patch in mice]. |
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| المؤلفون: | Yang HS; State Research Center for Research and Development of Traditional Chinese Medicine Multi-ingredient Drugs, Beijing 100075, China., Ye ZG, Liang BW, Wang NJ, He C, Li JS |
| المصدر: | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2008 Jun; Vol. 33 (12), pp. 1459-62. |
| نوع المنشور: | Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Country of Publication: China NLM ID: 8913656 Publication Model: Print Cited Medium: Print ISSN: 1001-5302 (Print) Linking ISSN: 10015302 NLM ISO Abbreviation: Zhongguo Zhong Yao Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing : Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Original Publication: [Beijing] : Zhongguo yao xue hui : [Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo, 1989- |
| مواضيع طبية MeSH: | Artemisinins/*administration & dosage , Artemisinins/*pharmacokinetics, Administration, Cutaneous ; Administration, Oral ; Animals ; Artemether ; Artemisinins/blood ; Artemisinins/metabolism ; Calibration ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/metabolism ; Drugs, Chinese Herbal/pharmacokinetics ; Male ; Mice ; Mice, Inbred ICR ; Sensitivity and Specificity ; Tandem Mass Spectrometry |
| مستخلص: | Objective: To establish a HPLC-MS-MS determination method of artemether (ARM) and active derivatives DHA, and compare the pharmacokinetic parameters of ARM after transdermal and oral administration. Method: The mice were divided two groups (transdermal and oral) by parallel design. ARM and active derivatives DHA in plasma of mice at different sampling time were determined. The pharmacokinetic parameters were calculated by DAS 2.0 and by statistic analysis. Result: compare oral administration, the pharmacokinetic parameters of ARM after transdermal, Cmax Tmax , AUC(0-t) MRT, had significant difference (P < 0.05). Conclusion: The artemether patch has long-releasing property. |
| المشرفين على المادة: | 0 (Artemisinins) 0 (Drugs, Chinese Herbal) C7D6T3H22J (Artemether) |
| تواريخ الأحداث: | Date Created: 20081008 Date Completed: 20090518 Latest Revision: 20181201 |
| رمز التحديث: | 20221213 |
| PMID: | 18837356 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1001-5302 |
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