دورية أكاديمية
Chronic hypokalemia and the left ventricular responses to epinephrine and preload.
| العنوان: | Chronic hypokalemia and the left ventricular responses to epinephrine and preload. |
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| المؤلفون: | Fitzovich DE; Department of Physiology and Biophysics, University of Mississippi School of Medicine, Jackson., Hamaguchi M, Tull WB, Young DB |
| المصدر: | Journal of the American College of Cardiology [J Am Coll Cardiol] 1991 Oct; Vol. 18 (4), pp. 1105-11. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8301365 Publication Model: Print Cited Medium: Print ISSN: 0735-1097 (Print) Linking ISSN: 07351097 NLM ISO Abbreviation: J Am Coll Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [New York, N.Y.] : Elsevier Biomedical, [c1983- |
| مواضيع طبية MeSH: | Epinephrine/*pharmacology , Hypokalemia/*physiopathology , Ventricular Function, Left/*physiology, Animals ; Chlorthalidone/pharmacology ; Dogs ; Hypokalemia/etiology ; Isotonic Solutions/pharmacology ; Myocardial Contraction/drug effects ; Potassium/administration & dosage ; Stroke Volume/drug effects |
| مستخلص: | The effects of moderate, chronic (5 days) potassium depletion on cardiac function were assessed in 14 normokalemic and 13 hypokalemic open chest, anesthetized dogs. Cardiac responses to intravenous bolus injection of 2.5 micrograms/kg body weight epinephrine (10 normokalemic and 11 hypokalemic dogs) and to rapidly increased preload (8 dogs in each group) were evaluated. Hypokalemic dogs received a low potassium diet plus chlorthalidone. Plasma potassium levels were lower (p less than 0.001) in the hypokalemic dogs (3.2 +/- 0.1 mEq/liter [mean +/- SEM]) than in the normokalemic dogs (4.1 +/- 0.1). The inotropic response to epinephrine was lower in hypokalemic than in normokalemic dogs, the response of the maximal rate of rise of left ventricular pressure was 20% greater (p less than 0.03) and the response of the peak rate of change of ejection power was 60% greater in the normokalemic dogs. The relaxation response to epinephrine (the maximal rate of fall of left ventricular pressure) was 33% lower (p less than 0.02) in hypokalemic dogs. Responses to rapid volume expansion were impaired by hypokalemia; maximal stroke volume index was 31% lower (p less than 0.01), maximal cardiac index was 26% lower (p less than 0.01) and the peak response to the maximal rate of filling was 51% lower (p less than 0.01). There were no differences in basal cardiac function. Therefore, modest potassium depletion within the clinical range impaired the contractile and relaxation responses to epinephrine and preload and impaired rapid filling. |
| معلومات مُعتمدة: | HL11678 United States HL NHLBI NIH HHS; HL21435 United States HL NHLBI NIH HHS |
| المشرفين على المادة: | 0 (Isotonic Solutions) 0 (Tyrode's solution) Q0MQD1073Q (Chlorthalidone) RWP5GA015D (Potassium) YKH834O4BH (Epinephrine) |
| تواريخ الأحداث: | Date Created: 19911001 Date Completed: 19911024 Latest Revision: 20190708 |
| رمز التحديث: | 20221208 |
| DOI: | 10.1016/0735-1097(91)90774-4 |
| PMID: | 1894855 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0735-1097 |
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| DOI: | 10.1016/0735-1097(91)90774-4 |