دورية أكاديمية
Sputum eosinophil apoptotic rate is positively correlated to exhaled nitric oxide in children.
| العنوان: | Sputum eosinophil apoptotic rate is positively correlated to exhaled nitric oxide in children. |
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| المؤلفون: | Pontin J; Department of Child Health, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK.; School of Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK., Blaylock MG; School of Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK., Walsh GM; School of Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK., Turner SW; Department of Child Health, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK. |
| المصدر: | Pediatric pulmonology [Pediatr Pulmonol] 2008 Nov; Vol. 43 (11), pp. 1130-1134. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8510590 Publication Model: Print Cited Medium: Internet ISSN: 1099-0496 (Electronic) Linking ISSN: 10990496 NLM ISO Abbreviation: Pediatr Pulmonol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005-> : Hoboken, NJ : Wiley-Liss Original Publication: [Philadelphia, PA] : W.B. Saunders, [c1985- |
| مواضيع طبية MeSH: | Apoptosis/*immunology , Asthma/*immunology , Eosinophilia/*immunology , Nitric Oxide/*analysis , Sputum/*immunology, Adolescent ; Biomarkers ; Breath Tests/methods ; Child ; Eosinophils/immunology ; Female ; Humans ; Male ; Nitric Oxide/immunology |
| مستخلص: | Rationale for Study: Exhaled nitric oxide (FE(NO)), a potential biomarker for asthma, is positively correlated with eosinophilic airway inflammation. Eosinophil apoptotic rate (AR) may be increased by NO but the relationship between eosinophil AR and NO has not been studied in vivo. This study tested the hypothesis that eosinophil AR will be positively related to FE(NO). Methods: Children with and without asthma were recruited and participated in an assessment that included FE(NO) measurement, skin prick reactivity, spirometry, and sputum induction. The absolute sputum eosinophil count and eosinophil AR were determined by morphology under light microscope after staining. Results: There were 31 children recruited, mean age 11 years, 21 were asthmatic and 19 were boys. The median FE(NO) (range) was 15.6 parts per billion (3.1-102.6), 17 were atopic and the mean (SD)% FEV(1) was 85 (10)%. Sputum eosinophil AR was determined in 19 children (16 asthmatics), mean (SD) value 0.49 (0.13). There were positive relationships between eosinophil AR and FE(NO) (Spearman rho = 0.46, P = 0.046), eosinophil AR and % eosinophil count (Spearman rho = 0.45, P = 0.050) and also FE(NO) and % eosinophil count (Spearman rho = 0.49, P = 0.024). Conclusion: There is a positive relationship between FE(NO) and eosinophil AR. Nitric oxide may be involved in regulation of eosinophil AR in the airways. ((c) 2008 Wiley-Liss, Inc.) |
| المشرفين على المادة: | 0 (Biomarkers) 31C4KY9ESH (Nitric Oxide) |
| تواريخ الأحداث: | Date Created: 20081031 Date Completed: 20090413 Latest Revision: 20180111 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1002/ppul.20921 |
| PMID: | 18972415 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1099-0496 |
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| DOI: | 10.1002/ppul.20921 |