دورية أكاديمية
أعرض في EDS

Human thyroid tumours, the puzzling lessons from E7 and RET/PTC3 transgenic mice.

التفاصيل البيبلوغرافية
العنوان: Human thyroid tumours, the puzzling lessons from E7 and RET/PTC3 transgenic mice.
المؤلفون: Jin L; Institut de Recherche Interdisciplinaire (IRIBHM), Faculté de Médecine, Université Libre de Bruxelles (ULB), Campus Erasme, Route de Lennik 808, B 1070 Bruxelles, Belgique. lingjin@ulb.ac.be, Burniat A, Dumont JE, Miot F, Corvilain B, Franc B
المصدر: British journal of cancer [Br J Cancer] 2008 Dec 02; Vol. 99 (11), pp. 1874-83. Date of Electronic Publication: 2008 Nov 04.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
أسماء مطبوعة: Publication: 2002- : London : Nature Publishing Group on behalf of Cancer Research UK
Original Publication: London, Lewis.
مواضيع طبية MeSH: Disease Models, Animal*, Adenocarcinoma, Papillary/*pathology , Papillomavirus E7 Proteins/*genetics , Proto-Oncogene Proteins c-ret/*genetics , Thyroid Neoplasms/*pathology, Adenocarcinoma, Papillary/genetics ; Adenocarcinoma, Papillary/metabolism ; Animals ; Cell Cycle ; Cell Proliferation ; Gene Expression ; Gene Expression Profiling ; Humans ; Immunohistochemistry ; Mice ; Mice, Transgenic ; Proto-Oncogene Mas ; Signal Transduction ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/metabolism
مستخلص: Human rearranged RET/PTC3 (papillary thyroid carcinoma) proto-oncogene and high-risk human papillomavirus (HPV) type 16 E7 oncogene induces in the mouse a neoplastic transformation of thyroid follicular cells. We present a detailed immuno-histological study (170 mouse thyroids: RET/PTC3, E7, wild type, 2- to 10-month-old) with cell cycle proliferation and signalling pathway indicators. The characteristics of both models are different. There is an 'oncogene dependent' cellular signature, maintained at all studied ages in the E7 model, less in the RET/PTC3 model. During tumour development a large heterogeneity occurred in the Tg-RET/PTC3 model within a same tumour or within a same thyroid lobe. The Tg-E7 model was less heterogeneous, with a dominant goitrous pattern. The solid tumour already described in the RET/PTC3 models associated with cribriform patterns, suggested 'PTC spindle cell changes' as in humans PTC rather than the equivalent of the solid human PTC. Proliferation and apoptosis in the two thyroid models are related to the causal oncogene rather than reflect a general tumorigenic process. The thyroids of RET/PTC3 mice appeared as a partial and transient model of human PTCs, whereas the Tg-E7 mice do not belong to the usual PTC type.
التعليقات: Erratum in: Br J Cancer. 2009 Mar 24;100(6):1013.
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المشرفين على المادة: 0 (MAS1 protein, human)
0 (Papillomavirus E7 Proteins)
0 (Proto-Oncogene Mas)
EC 2.7.10.1 (Proto-Oncogene Proteins c-ret)
تواريخ الأحداث: Date Created: 20081106 Date Completed: 20081230 Latest Revision: 20211203
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC2600679
DOI: 10.1038/sj.bjc.6604740
PMID: 18985036
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-1827
DOI:10.1038/sj.bjc.6604740