دورية أكاديمية
أعرض في EDS

Evidence of an age-related threshold effect of polychlorinated biphenyls (PCBs) on neuropsychological functioning in a Native American population.

التفاصيل البيبلوغرافية
العنوان: Evidence of an age-related threshold effect of polychlorinated biphenyls (PCBs) on neuropsychological functioning in a Native American population.
المؤلفون: Haase RF; Division of Counseling Psychology, Department of Educational and Counseling Psychology, University at Albany, State University of New York, ED 220, 1400 Washington Avenue, Albany, NY 12222, USA. rfh64@albany.edu, McCaffrey RJ, Santiago-Rivera AL, Morse GS, Tarbell A
المصدر: Environmental research [Environ Res] 2009 Jan; Vol. 109 (1), pp. 73-85. Date of Electronic Publication: 2008 Nov 28.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0147621 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0953 (Electronic) Linking ISSN: 00139351 NLM ISO Abbreviation: Environ Res Subsets: MEDLINE
أسماء مطبوعة: Publication: <2000- > : Amsterdam : Elsevier
Original Publication: New York, Academic Press.
مواضيع طبية MeSH: Aging*/blood , Aging*/drug effects , Aging*/psychology , Environmental Exposure*/adverse effects , Environmental Exposure*/analysis , Environmental Pollutants*/blood , Environmental Pollutants*/toxicity , Indians, North American*/psychology , Polychlorinated Biphenyls*/blood , Polychlorinated Biphenyls*/toxicity, Adolescent ; Adult ; Aged ; Body Burden ; Female ; Humans ; Male ; Memory/drug effects ; Middle Aged ; Motor Activity/drug effects ; Neuropsychological Tests ; New York ; Regression Analysis ; Young Adult
مستخلص: Polychlorinated biphenyls (PCBs) have been suspected for some time of having adverse effects on neuropsychological functioning in humans. While there is evidence of slowing of cognitive function in children associated with exposure to PCBs, the evidence of comparable effects on adults is far less well understood. We report here on the neuropsychological evaluation of 277 Native American adults, ranging in age from 18 to 79, who were exposed to PCBs by way of environmental contamination in the St. Lawrence region of upstate New York. PCB body burden was estimated by 101 PCB congeners and neuropsychological functioning was assessed by a battery of 18 tests. Spline regression models were fitted to the latent variables of memory, motor function, and higher-order executive functioning. After adjusting for age, gender, and education the analyses revealed a threshold effect of PCBs at approximately 2 ppb. An age-by-PCB interaction effect was also observed for several variables which suggests that the threshold effect was largely confined to the age range of 40-79 and was not observable in the 18-40-year-old group. Implications of these results are discussed in comparison to previously published similar work with adults and in terms of its potential clinical meaningfulness.
التعليقات: Comment in: Environ Res. 2009 Jul;109(5):647-8. (PMID: 19393993)
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معلومات مُعتمدة: P42 ES004913-080013 United States ES NIEHS NIH HHS; P42 ES004913-10 United States ES NIEHS NIH HHS; P24 ES04913 United States ES NIEHS NIH HHS
المشرفين على المادة: 0 (Environmental Pollutants)
DFC2HB4I0K (Polychlorinated Biphenyls)
تواريخ الأحداث: Date Created: 20081202 Date Completed: 20090112 Latest Revision: 20240312
رمز التحديث: 20240312
مُعرف محوري في PubMed: PMC2644409
DOI: 10.1016/j.envres.2008.10.003
PMID: 19041090
قاعدة البيانات: MEDLINE
الوصف
تدمد:1096-0953
DOI:10.1016/j.envres.2008.10.003