دورية أكاديمية
Increased incidence of sterile endophthalmitis after intravitreal triamcinolone acetonide in spring 2006.
| العنوان: | Increased incidence of sterile endophthalmitis after intravitreal triamcinolone acetonide in spring 2006. |
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| المؤلفون: | Stepien KE; Bascom Palmer Eye Institute, University of Miami School of Medicine, USA., Eaton AM, Jaffe GJ, Davis JL, Raja J, Feuer W |
| المصدر: | Retina (Philadelphia, Pa.) [Retina] 2009 Feb; Vol. 29 (2), pp. 207-13. |
| نوع المنشور: | Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8309919 Publication Model: Print Cited Medium: Internet ISSN: 1539-2864 (Electronic) Linking ISSN: 0275004X NLM ISO Abbreviation: Retina Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: Philadelphia : Lippincott, [1981?- |
| مواضيع طبية MeSH: | Seasons*, Endophthalmitis/*chemically induced , Glucocorticoids/*adverse effects , Triamcinolone Acetonide/*adverse effects, Aged ; Aged, 80 and over ; Endophthalmitis/diagnosis ; Female ; Humans ; Incidence ; Injections ; Male ; Middle Aged ; Preservatives, Pharmaceutical ; Retrospective Studies ; Risk Factors ; Time Factors ; Vitreous Body |
| مستخلص: | Purpose: To compare the incidence of sterile endophthalmitis after intravitreal triamcinolone acetonide injections during a 6 month period in 2006 to the same period in 2005 and determine the incidence after switching to intravitreal preservative-free triamcinolone acetonide. Methods: Retrospective multicenter interventional case series in which patients receiving intravitreal triamcinolone acetonide at three institutions from March 2005 to August 2005 and from March 2006 to August 2006 and intravitreal preservative-free triamcinolone acetonide from late summer 2006 through February 2007 were reviewed for the development of sterile endophthalmitis. Results: From March 2005 to August 2005, the rate of sterile endophthalmitis was 0% at all institutions. From March 2006 to August 2006, a statistically significant increase in sterile endophthalmitis was seen at all institutions with frequencies of 3.5% to 6.3% (P < 0.001). With transition to preservative-free triamcinolone acetonide, sterile endophthalmitis over the next 6 months decreased to 0% at two sites and to 2.5% (from 5.5%) at the third institution (P < 0.009). Conclusions: A statistically significant increase in the rate of sterile endophthalmitis after intravitreal triamcinolone acetonide was seen in a 6 month period in 2006 when compared with the same period in 2005. Transition to preservative-free triamcinolone acetonide produced a frequency of sterile endophthalmitis similar to 2005. |
| معلومات مُعتمدة: | P30 EY014801 United States EY NEI NIH HHS |
| المشرفين على المادة: | 0 (Glucocorticoids) 0 (Preservatives, Pharmaceutical) F446C597KA (Triamcinolone Acetonide) |
| تواريخ الأحداث: | Date Created: 20081204 Date Completed: 20090331 Latest Revision: 20131121 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1097/IAE.0b013e31818eccb3 |
| PMID: | 19050670 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1539-2864 |
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| DOI: | 10.1097/IAE.0b013e31818eccb3 |