دورية أكاديمية
أعرض في EDS

Risk score derived from pre-operative data analysis predicts the need for biventricular mechanical circulatory support.

التفاصيل البيبلوغرافية
العنوان: Risk score derived from pre-operative data analysis predicts the need for biventricular mechanical circulatory support.
المؤلفون: Fitzpatrick JR 3rd; Division of Cardiovascular Surgery, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Frederick JR, Hsu VM, Kozin ED, O'Hara ML, Howell E, Dougherty D, McCormick RC, Laporte CA, Cohen JE, Southerland KW, Howard JL, Jessup ML, Morris RJ, Acker MA, Woo YJ
المصدر: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation [J Heart Lung Transplant] 2008 Dec; Vol. 27 (12), pp. 1286-92.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 9102703 Publication Model: Print Cited Medium: Internet ISSN: 1557-3117 (Electronic) Linking ISSN: 10532498 NLM ISO Abbreviation: J Heart Lung Transplant Subsets: MEDLINE
أسماء مطبوعة: Publication: 1999- : New York, NY : Elsevier
Original Publication: St. Louis, Mo. : Mosby-Year Book, Inc., c1991-
مواضيع طبية MeSH: Heart Transplantation* , Heart-Assist Devices*/adverse effects, Heart Failure/*physiopathology , Ventricular Dysfunction, Left/*surgery , Ventricular Dysfunction, Right/*surgery, Adult ; Aged ; Blood Pressure ; Diabetes Complications/epidemiology ; Equipment Design ; Female ; Heart Failure/surgery ; Hemodynamics ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Ventricular Dysfunction, Left/epidemiology ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Dysfunction, Right/physiopathology ; Ventricular Function, Right
مستخلص: Background: Right ventricular (RV) failure after left ventricular assist device (LVAD) placement is a serious complication and is difficult to predict. In the era of destination therapy and the total artificial heart, predicting post-LVAD RV failure requiring mechanical support is extremely important.
Methods: We reviewed patient characteristics, laboratory values and hemodynamic data from 266 patients who underwent LVAD placement at the University of Pennsylvania from April 1995 to June 2007.
Results: Of 266 LVAD recipients, 99 required RV assist device (BiVAD) placement (37%). We compared 36 parameters between LVAD (n = 167) and BiVAD patients (n = 99) to determine pre-operative risk factors for RV assist device (RVAD) need. By univariate analysis, 23 variables showed statistically significant differences between the two groups (p < or = 0.05). By multivariate logistic regression, cardiac index < or =2.2 liters/min/m(2) (odds ratio [OR] 5.7), RV stroke work index < or =0.25 mm Hg . liter/m(2) (OR 5.1), severe pre-operative RV dysfunction (OR 5.0), pre-operative creatinine > or =1.9 mg/dl (OR 4.8), previous cardiac surgery (OR 4.5) and systolic blood pressure < or =96 mm Hg (OR 2.9) were the best predictors of RVAD need.
Conclusions: The most significant predictors for RVAD need were cardiac index, RV stroke work index, severe pre-operative RV dysfunction, creatinine, previous cardiac surgery and systolic blood pressure. Using these data, we constructed an algorithm that can predict which LVAD patients will require RVAD with >80% sensitivity and specificity.
التعليقات: Comment in: J Heart Lung Transplant. 2011 Dec;30(12):1419. (PMID: 21925904)
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معلومات مُعتمدة: K08 HL072812 United States HL NHLBI NIH HHS; K08 HL072812-02 United States HL NHLBI NIH HHS; K08 HL072812-03 United States HL NHLBI NIH HHS; K08 HL072812-04 United States HL NHLBI NIH HHS
تواريخ الأحداث: Date Created: 20081209 Date Completed: 20090619 Latest Revision: 20220408
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3235680
DOI: 10.1016/j.healun.2008.09.006
PMID: 19059108
قاعدة البيانات: MEDLINE
الوصف
تدمد:1557-3117
DOI:10.1016/j.healun.2008.09.006