دورية أكاديمية
No association between common chemokine and chemokine receptor gene variants and prostate cancer risk.
| العنوان: | No association between common chemokine and chemokine receptor gene variants and prostate cancer risk. |
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| المؤلفون: | Petersen DC; Cancer Genetics Group, Children's Cancer Institute Australia, Level 1, Sydney Children's Hospital, P.O. Box 81, High Street, Randwick, New South Wales 2031, Australia., Severi G, Hoang HN, Padilla EJ, Southey MC, English DR, Hopper JL, Giles GG, Hayes VM |
| المصدر: | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2008 Dec; Vol. 17 (12), pp. 3615-7. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9200608 Publication Model: Print Cited Medium: Print ISSN: 1055-9965 (Print) Linking ISSN: 10559965 NLM ISO Abbreviation: Cancer Epidemiol Biomarkers Prev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, PA : American Association for Cancer Research, c1991- |
| مواضيع طبية MeSH: | Genetic Variation*, Chemokines/*genetics , Prostatic Neoplasms/*genetics , Receptors, CCR5/*genetics , Receptors, Chemokine/*genetics, Case-Control Studies ; Genotype ; Humans ; Logistic Models ; Male |
| مستخلص: | There is growing evidence that inflammation and infection play important roles in the etiology of prostate cancer. As the chemokine network is directly involved in inflammation and infectious diseases, we tested for an association between six common putative functional variants and prostate cancer risk using an Australian case-control study. We measured CCL5 -403G>A, CXCL12 +801G>A, CCR2V64I (G>A), CCR5Delta32, CX3CR1V249I (G>A), and CX3CR1T280M (C>T) for 815 cases and 738 controls. Of these, only CXCL12 +801G>A has previously been tested and found to be associated with prostate cancer risk. We found no significant associations with prostate cancer risk (all P > 0.4). All per allele odds ratios ranged from 0.96 (95% confidence intervals, 0.80-1.16) to 1.06 (95% confidence intervals, 0.90-1.23). This suggests that these common chemokine and chemokine receptor variants do not play a major, if any, role in susceptibility to prostate cancer. |
| المشرفين على المادة: | 0 (Chemokines) 0 (Receptors, CCR5) 0 (Receptors, Chemokine) |
| تواريخ الأحداث: | Date Created: 20081210 Date Completed: 20090127 Latest Revision: 20081209 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1158/1055-9965.EPI-08-0896 |
| PMID: | 19064579 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1055-9965 |
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| DOI: | 10.1158/1055-9965.EPI-08-0896 |