دورية أكاديمية
Nmur1-/- mice are not protected from cutaneous inflammation.
| العنوان: | Nmur1-/- mice are not protected from cutaneous inflammation. |
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| المؤلفون: | Abbondanzo SJ; Department of Discovery Technology, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA. susan.abbondanzo@spcorp.com, Manfra DJ, Chen SC, Pinzon-Ortiz M, Sun Y, Phillips JE, Laverty M, Vassileva G, Hu W, Yang S, Gustafson EL, Fine JS, Hedrick JA |
| المصدر: | Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2009 Jan 23; Vol. 378 (4), pp. 777-82. Date of Electronic Publication: 2008 Dec 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2002- >: San Diego, CA : Elsevier Original Publication: New York, Academic Press. |
| مواضيع طبية MeSH: | Dermatitis/*immunology , Receptors, Neurotransmitter/*physiology, Animals ; Cytokines/blood ; Dermatitis/genetics ; Freund's Adjuvant/immunology ; Freund's Adjuvant/pharmacology ; Gene Deletion ; Mice ; Mice, Knockout ; Receptors, Neurotransmitter/genetics |
| مستخلص: | Neuromedin U (Nmu) is a neuropeptide expressed primarily in the gastrointestinal tract and central nervous system. Previous reports have identified two G protein-coupled receptors (designated Nmur1 and Nmur2) that bind Nmu. Recent reports suggest that Nmu mediates immune responses involving mast cells, and Nmur1 has been proposed to mediate these responses. In this study, we generated mice with an Nmur1 deletion and then profiled the responses of these mice in a cutaneous inflammation model utilizing complete Freund's adjuvant (CFA). We report here that mice lacking Nmur1 had normal inflammation responses with moderate changes in serum cytokines compared to Nmur1(+/+) littermates. Although differences in IL-6 were observed in mice lacking Nmu peptide, these mice exhibited a normal response to CFA. Our data argues against a major role for Nmur1 in mediating the reported inflammatory functions of NmU. |
| المشرفين على المادة: | 0 (Cytokines) 0 (Receptors, Neurotransmitter) 0 (neuromedin U receptor) 9007-81-2 (Freund's Adjuvant) |
| تواريخ الأحداث: | Date Created: 20081217 Date Completed: 20090122 Latest Revision: 20081230 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.bbrc.2008.11.148 |
| PMID: | 19070594 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1090-2104 |
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| DOI: | 10.1016/j.bbrc.2008.11.148 |