دورية أكاديمية
[Age as an independent prognostic factor in breast cancer].
| العنوان: | [Age as an independent prognostic factor in breast cancer]. |
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| عنوان ترانسليتريتد: | Idade como fator independente de prognóstico no câncer de mama. |
| المؤلفون: | Clagnan WS; Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Avenida Bandeirantes 3.900, Ribeirão Preto, SP, Brazil., Andrade JM, Carrara HH, Tiezzi DG, Reis FJ, Marana HR, Abrão RA |
| المصدر: | Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia [Rev Bras Ginecol Obstet] 2008 Feb; Vol. 30 (2), pp. 67-74. |
| نوع المنشور: | Comparative Study; English Abstract; Journal Article |
| اللغة: | Portuguese |
| بيانات الدورية: | Publisher: Federação das Sociedades de Ginecologia e Obstetrícia Country of Publication: Brazil NLM ID: 9214757 Publication Model: Print Cited Medium: Internet ISSN: 1806-9339 (Electronic) Linking ISSN: 01007203 NLM ISO Abbreviation: Rev Bras Ginecol Obstet Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2024- : São Paulo : Federação das Sociedades de Ginecologia e Obstetrícia Original Publication: [São Paulo, Brazil] : Medisa Editora |
| مواضيع طبية MeSH: | Breast Neoplasms/*diagnosis , Breast Neoplasms/*epidemiology, Adult ; Age Distribution ; Age Factors ; Case-Control Studies ; Female ; Humans ; Middle Aged ; Prognosis ; Retrospective Studies |
| مستخلص: | Purpose: to compare the epidemiologic and clinical characteristics, and the follow-up of breast cancer in women diagnosed under and over 40 years of age. Methods: a retrospective study, case-control type, with analysis of information obtained from medical records of patients attended from January 1994 to June 2004. Cases of intraductal carcinoma and at stage IV were excluded. Three groups were formed: patients under 40 years old at the diagnosis (n=72); patients between 40 and 50 (n=68) and patients over 50 (n=75). Data about age at the moment of diagnosis, lesion largest diameter, clinical stage, type, histological grade, presence of hormonal receptors and state of the lymph nodes were collected and analyzed. The chi2 test was used for qualitative variables. For quantitative variables without normal distribution (such as number of axillary nodes with metastasis and follow-up duration), the Kruskal-Wallis' test was used. For delineating the curves of free-of-disease and global survival, the log-rank test was used. Results: there was no difference among the groups in the stage distribution, concerning the tumoral differentiation grade or in the distribution of histological types, and in the estrogen receptor and c-erb-B2 expression. Difference was found in the RP expression, which was less frequent in the group of patients under 40, than in the group of patients over 50 (36.2% versus 58.4%) respectively. There was no difference among the groups in the mean tumoral diameter (5.1, 4.7 and 5 cm, respectively). There was also no difference among the groups, concerning the rate of axillary lymph node metastasis (63.9, 46.9 and 50%, respectively). The average follow-up was 54 months for all the groups. Disease recurrence occurred in 22.6% of patients under 40 years old, in 60% of patients between 40 and 50, and in 22.6% of patients over 50, with a significant difference among groups (p<0.0001). Death caused by the disease was higher among patients under 40 (46.9%) than among patients between 40 and 50 (26.9%) and over 50 (22.6%), p=0.0019. The logistic analysis showed that 'age under 40' and the 'presence of more than one metastatic axillary node' were independent death risk factors. Conclusions: age under 40 is an independent risk factor for breast cancer. The traditional prognostic indicators, such as stage, tumoral diameter, axillary involvement and presence of hormonal receptors are not associated with the disease evolution. |
| تواريخ الأحداث: | Date Created: 20090115 Date Completed: 20090622 Latest Revision: 20191111 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1590/s0100-72032008000200004 |
| PMID: | 19142478 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1806-9339 |
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| DOI: | 10.1590/s0100-72032008000200004 |