دورية أكاديمية
[New liposomal forms of antifungal antibiotics, modified by amphiphilic polymers].
| العنوان: | [New liposomal forms of antifungal antibiotics, modified by amphiphilic polymers]. |
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| المؤلفون: | Iamskov IA, Kuskov AN, Babievskiĭ KK, Berezin BB, Kraiukhina MA, Samoĭlova NA, Tikhonov VE, Shtil'man MI |
| المصدر: | Prikladnaia biokhimiia i mikrobiologiia [Prikl Biokhim Mikrobiol] 2008 Nov-Dec; Vol. 44 (6), pp. 688-93. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Izdatelstvo Nauka Country of Publication: Russia (Federation) NLM ID: 0023416 Publication Model: Print Cited Medium: Print ISSN: 0555-1099 (Print) Linking ISSN: 05551099 NLM ISO Abbreviation: Prikl Biokhim Mikrobiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : Izdatelstvo Nauka |
| مواضيع طبية MeSH: | Amphotericin B/*chemistry , Antifungal Agents/*chemistry , Lipids/*chemistry , Nystatin/*chemistry , Pyrrolidinones/*chemistry, Liposomes ; Octoxynol/chemistry |
| مستخلص: | A method has been developed, for incorporating macrocyclic polyene antibiotics nistatin and amphotericin B into liposomes containing phosphatidylcholine and cholesterol (7:3) or phosphatidylcholine, cholesterol, and cardiolipin (7:3:1), the membranes of which were modified with an amphiphilic polymer of N-vinylpyrrolidone, carrying one terminal n-octadecyl group and having a molecular weight of 4000 Da. The amount of antibiotics within such liposomal nanocarriers may be as high as 17-22%. It was demonstrated that the modified liposomes have sizes in the range 150-200 nm and exhibit increased long-term storage stability and increased resistance to disrupting agents (Triton X-100 or ethanol) and ultrasound. The antifungal activity of the liposomal preparations obtained exceeded that of the antibiotics not subjected to immobilization. |
| المشرفين على المادة: | 0 (Antifungal Agents) 0 (Lipids) 0 (Liposomes) 0 (Pyrrolidinones) 1400-61-9 (Nystatin) 76H9G81541 (N-vinyl-2-pyrrolidinone) 7XU7A7DROE (Amphotericin B) 9002-93-1 (Octoxynol) |
| تواريخ الأحداث: | Date Created: 20090117 Date Completed: 20090217 Latest Revision: 20131121 |
| رمز التحديث: | 20221213 |
| PMID: | 19145977 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0555-1099 |
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