التفاصيل البيبلوغرافية
| العنوان: |
Ultrasound-enhanced drug and gene delivery: a review. |
| المؤلفون: |
Zderic V; Department of Electrical and Computer Engineering, The George Washington University, USA. |
| المصدر: |
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference [Annu Int Conf IEEE Eng Med Biol Soc] 2008; Vol. 2008, pp. 4472. |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: [IEEE] Country of Publication: United States NLM ID: 101763872 Publication Model: Print Cited Medium: Print ISSN: 2375-7477 (Print) Linking ISSN: 23757477 NLM ISO Abbreviation: Annu Int Conf IEEE Eng Med Biol Soc Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: [Piscataway, NJ] : [IEEE], [2007]- |
| مواضيع طبية MeSH: |
Gene Transfer Techniques* , Ultrasonics*, Drug Delivery Systems ; Genetic Vectors ; Humans ; Technology, Pharmaceutical/methods ; Transfection |
| مستخلص: |
Optimization of drug and gene delivery is currently a topic of great interest. This optimization can be achieved via sitespecific (targeted) delivery, controlled drug release, and by finding ways to deliver more of the drug into tissues of interest (despite various barriers). Targeted delivery can serve to lower the required drug dose and minimize toxic side effects, which is crucial for the success of cancer chemotherapy. Controlled release of drugs can be advantageous in the management of chronic diseases such as diabetes and hypertension. In recent years, application of ultrasound in the enhancement of drug delivery, controlled drug release, and site-specific delivery has been a topic of extensive research. Ultrasound was shown to improve delivery of thrombolytic agents, anticancer drugs, genes, and macromolecules into different tissues. This enhancement is believed to be due mostly to cavitation activity and streaming. Specifically, ultrasound was previously used for controlled release of insulin through the skin, targeted gene transfection into cardiac cells, delivery of medications through blood-brain and eye barriers, treatment of stroke, etc. This review talk will cover recent developments in various areas of ultrasound-enhanced drug and gene delivery. |
| تواريخ الأحداث: |
Date Created: 20090124 Date Completed: 20090511 Latest Revision: 20200928 |
| رمز التحديث: |
20240628 |
| DOI: |
10.1109/IEMBS.2008.4650205 |
| PMID: |
19163708 |
| قاعدة البيانات: |
MEDLINE |
