دورية أكاديمية
[OCT4 and NANOG are the key genes in the system of pluripotency maintenance in mammalian cells].
| العنوان: | [OCT4 and NANOG are the key genes in the system of pluripotency maintenance in mammalian cells]. |
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| المؤلفون: | Medvedev SP, Shevchenko AI, Mazurok NA, Zakiian SM |
| المصدر: | Genetika [Genetika] 2008 Dec; Vol. 44 (12), pp. 1589-608. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Izdatelstvo Nauka Country of Publication: Russia (Federation) NLM ID: 0047354 Publication Model: Print Cited Medium: Print ISSN: 0016-6758 (Print) Linking ISSN: 00166758 NLM ISO Abbreviation: Genetika Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : Izdatelstvo Nauka |
| مواضيع طبية MeSH: | Cell Differentiation/*physiology , Embryonic Stem Cells/*metabolism , Gene Expression Regulation, Developmental/*physiology , Homeodomain Proteins/*metabolism , Octamer Transcription Factor-3/*metabolism , Pluripotent Stem Cells/*metabolism, Animals ; Blastocyst/cytology ; Blastocyst/metabolism ; Embryo, Mammalian/cytology ; Embryo, Mammalian/metabolism ; Embryonic Stem Cells/cytology ; Germ Layers/cytology ; Germ Layers/metabolism ; Homeodomain Proteins/genetics ; Humans ; Nanog Homeobox Protein ; Octamer Transcription Factor-3/genetics ; Pluripotent Stem Cells/cytology |
| مستخلص: | Embryonic stem cells are able to give rise after differentiation to derivatives of three germinal layers (ectoderm, endoderm, and mesoderm) and to functional gametes. This property of cells is referred to as pluripotency. The pluripotent status of preimplantation embryo cells and embryonic stem cells is maintained by a complicated system of molecular signaling pathways and transcription factors. The key regulators in this system are the transcription factors OCT4 and NANOG. The role and place of these factors in the pluripotency-sustaining system and their interaction with other factors are considered in the review. Data are presented on the structure, chromosomal location, expression, and regulation of the Oct4 and Nanog genes in mammals. |
| Number of References: | 111 |
| المشرفين على المادة: | 0 (Homeodomain Proteins) 0 (NANOG protein, human) 0 (Nanog Homeobox Protein) 0 (Octamer Transcription Factor-3) 0 (POU5F1 protein, human) |
| تواريخ الأحداث: | Date Created: 20090131 Date Completed: 20090217 Latest Revision: 20201215 |
| رمز التحديث: | 20240628 |
| PMID: | 19178078 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0016-6758 |
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