دورية أكاديمية
[Isolation and synthesis of espintanol, a new antiparasitic monoterpene].
| العنوان: | [Isolation and synthesis of espintanol, a new antiparasitic monoterpene]. |
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| عنوان ترانسليتريتد: | Isolement et synthese de l'espintanol, nouveau monoterpene antiparasitaire. |
| المؤلفون: | Hocquemiller R; Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université Paris, France., Cortes D, Arango GJ, Myint SH, Cavé A, Angelo A, Muñoz V, Fournet A |
| المصدر: | Journal of natural products [J Nat Prod] 1991 Mar-Apr; Vol. 54 (2), pp. 445-52. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | French |
| بيانات الدورية: | Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print Cited Medium: Print ISSN: 0163-3864 (Print) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cincinnati, American Society of Pharmacognosy. |
| مواضيع طبية MeSH: | Antiprotozoal Agents*/chemical synthesis , Antiprotozoal Agents*/isolation & purification, Plants/*chemistry , Terpenes/*pharmacology, Animals ; Cell Line ; Humans ; Leishmania/drug effects ; Leishmania mexicana ; Leishmaniasis/drug therapy ; Male ; Mice ; Mice, Inbred BALB C ; Molecular Structure ; Terpenes/chemical synthesis ; Terpenes/isolation & purification ; Trypanosoma cruzi/drug effects |
| مستخلص: | The in vitro leishmanicidal and trypanocidal activities of a petroleum ether extract of Oxandra espintana have been investigated. Four aromatic monoterpenes were isolated, of which two are novel: espintanol [3a], responsible for the antiparasite activity, and O-methylespintanol [4]. Espintanol was tested in vitro on 20 strains of Trypanosoma cruzi and 12 strains of Leishmania spp. Its structure was determined by spectroscopic methods and confirmed by its preparation starting from carvacrol. |
| المشرفين على المادة: | 0 (Antiprotozoal Agents) 0 (Terpenes) |
| تواريخ الأحداث: | Date Created: 19910301 Date Completed: 19911108 Latest Revision: 20190903 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1021/np50074a015 |
| PMID: | 1919589 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 0163-3864 |
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| DOI: | 10.1021/np50074a015 |