دورية أكاديمية
[Epidemiological features of invasive pneumococcal disease before and after the introduction of pneumococcal conjugate vaccine in Gran Canaria (Canary Islands)].
| العنوان: | [Epidemiological features of invasive pneumococcal disease before and after the introduction of pneumococcal conjugate vaccine in Gran Canaria (Canary Islands)]. |
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| عنوان ترانسليتريتد: | Aspectos epidemiológicos de la enfermedad neumocócica invasiva antes y después del uso de la vacuna neumocócica conjugada en Gran Canaria. |
| المؤلفون: | Artiles F; Servicio de Microbiología, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, España. fartcam@gobiernodecanarias.org, Horcajada I, Cañas AM, Alamo I, Bordes A, González A, Santana M, Lafarga B |
| المصدر: | Enfermedades infecciosas y microbiologia clinica [Enferm Infecc Microbiol Clin] 2009 Jan; Vol. 27 (1), pp. 14-21. Date of Electronic Publication: 2009 Jan 09. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Spanish; Castilian |
| بيانات الدورية: | Publisher: Elsevier España Country of Publication: Spain NLM ID: 9104081 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0213-005X (Print) Linking ISSN: 0213005X NLM ISO Abbreviation: Enferm Infecc Microbiol Clin Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Madrid : Elsevier España Original Publication: Barcelona : Ediciones Doyma, SL c1984- |
| مواضيع طبية MeSH: | Pneumococcal Vaccines*, Pneumococcal Infections/*epidemiology , Streptococcus pneumoniae/*isolation & purification, Adolescent ; Adult ; Anti-Bacterial Agents/pharmacology ; Child ; Child, Preschool ; Drug Resistance, Multiple, Bacterial ; Female ; Humans ; Incidence ; Infant ; Male ; Morbidity/trends ; Pneumococcal Infections/microbiology ; Pneumococcal Infections/prevention & control ; Population Surveillance ; Retrospective Studies ; Serotyping ; Spain/epidemiology ; Streptococcus pneumoniae/classification ; Streptococcus pneumoniae/drug effects ; Streptococcus pneumoniae/immunology ; Vaccination ; Vaccines, Conjugate |
| مستخلص: | Introduction: The introduction of pneumococcal conjugate vaccine (PCV-7) has modified the epidemiology of invasive pneumococcal disease (IPD). Our aim was to investigate the epidemiological features of IPD before and after implementing the use of PCV-7. Methods: All invasive Streptococcus pneumoniae strains isolated in our hospital from 2000 to 2006 were included. Serotypes were identified and antibiograms were performed in all cases. Data obtained before (2000-2001) and after (2004-2006) authorization of PCV-7 use in Spain were compared. Results: There were 241 cases of IPD. None of the patients with IPD aged 2 years or younger had received PCV-7. PCV-7 coverage in children aged 5 or younger was about 48%. There was a non-significant increase in the incidence of IPD in children (from 53.8 to 57.8 cases/100 000 population), with no change in adults. When IPD incidence was adjusted by the number of blood samples collected, there was a non-significant decrease in both children and adults. Since PCV-7 came on the market, there has been a decrease in vaccine serotypes and an increase in non-vaccine serotypes. The emergent serotypes since that time include 3, 6A, 15, and 19A. Penicillin resistance decreased significantly (p<0.001) from the pre-vaccine period (87.3%) to 2003 (13.8%), and later rose from 2003 through 2006 (41.7%). Erythromycin resistance showed no changes during the study. Conclusions: The incidence of IPD in children aged 2 years and younger in Gran Canaria has not decreased despite the introduction of PCV-7. However, there has been a reduction in the number of cases related to vaccine serotypes and a significant decrease in penicillin resistance. In contrast, non-vaccine serotype IPD cases have increased. Universal vaccination and the use of new polyvalent vaccines may enhance these effects. |
| التعليقات: | Comment in: Enferm Infecc Microbiol Clin. 2009 Jan;27(1):1-4. (PMID: 19217995) |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Pneumococcal Vaccines) 0 (Vaccines, Conjugate) |
| تواريخ الأحداث: | Date Created: 20090217 Date Completed: 20090521 Latest Revision: 20090216 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.eimc.2008.03.001 |
| PMID: | 19217998 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0213-005X |
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| DOI: | 10.1016/j.eimc.2008.03.001 |