دورية أكاديمية
أعرض في EDS

Noninvasive multimodality imaging of the tumor microenvironment: registered dynamic magnetic resonance imaging and positron emission tomography studies of a preclinical tumor model of tumor hypoxia.

التفاصيل البيبلوغرافية
العنوان: Noninvasive multimodality imaging of the tumor microenvironment: registered dynamic magnetic resonance imaging and positron emission tomography studies of a preclinical tumor model of tumor hypoxia.
المؤلفون: Cho H; Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA., Ackerstaff E, Carlin S, Lupu ME, Wang Y, Rizwan A, O'Donoghue J, Ling CC, Humm JL, Zanzonico PB, Koutcher JA
المصدر: Neoplasia (New York, N.Y.) [Neoplasia] 2009 Mar; Vol. 11 (3), pp. 247-59, 2p following 259.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 100886622 Publication Model: Print Cited Medium: Internet ISSN: 1476-5586 (Electronic) Linking ISSN: 14765586 NLM ISO Abbreviation: Neoplasia Subsets: MEDLINE
أسماء مطبوعة: Publication: 2014- : [Amsterdam] : Elsevier
Original Publication: New York, NY : Stockton Press, c1999-
مواضيع طبية MeSH: Cell Hypoxia*, Magnetic Resonance Imaging/*methods , Positron-Emission Tomography/*methods , Prostatic Neoplasms/*pathology, Animals ; Autoradiography ; Disease Models, Animal ; Image Processing, Computer-Assisted ; Male ; Misonidazole/analogs & derivatives ; Nitroimidazoles ; Radiopharmaceuticals ; Rats
مستخلص: In vivo knowledge of the spatial distribution of viable, necrotic, and hypoxic areas can provide prognostic information about the risk of developing metastases and regional radiation sensitivity and may be used potentially for localized dose escalation in radiation treatment. In this study, multimodality in vivo magnetic resonance imaging (MRI) and positron emission tomography (PET) imaging using stereotactic fiduciary markers in the Dunning R3327-AT prostate tumor were performed, focusing on the relationship between dynamic contrast-enhanced (DCE) MRI using Magnevist (Gd-DTPA) and dynamic (18)F-fluoromisonidazole ((18)F-Fmiso) PET. The noninvasive measurements were verified using tumor tissue sections stained for hematoxylin/eosin and pimonidazole. To further validate the relationship between (18)F-Fmiso and pimonidazole uptake, (18)F digital autoradiography was performed on a selected tumor and compared with the corresponding pimonidazole-stained slices. The comparison of Akep values (kep = rate constant of movement of Gd-DTPA between the interstitial space and plasma and A = amplitude in the two-compartment model (Hoffmann U, Brix G, Knopp MV, Hess T and Lorenz WJ (1995). Magn Reson Med 33, 506-514) derived from DCE-MRI studies and from early (18)F-Fmiso uptake PET studies showed that tumor vasculature is a major determinant of early (18)F-Fmiso uptake. A negative correlation between the spatial map of Akep and the slope map of late (last 1 hour of the dynamic PET scan) (18)F-Fmiso uptake was observed. The relationships between DCE-MRI and hematoxylin/eosin slices and between (18)F-Fmiso PET and pimonidazole slices confirm the validity of MRI/PET measurements to image the tumor microenvironment and to identify regions of tumor necrosis, hypoxia, and well-perfused tissue.
التعليقات: Erratum in: Neoplasia. 2016 Dec;18(12 ):811. (PMID: 27978998)
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معلومات مُعتمدة: P50 CA086438 United States CA NCI NIH HHS; P30 CA08748 United States CA NCI NIH HHS; P50 CA86438 United States CA NCI NIH HHS; P30 CA008748 United States CA NCI NIH HHS; P01 CA115675-040001 United States CA NCI NIH HHS; R24 CA83084 United States CA NCI NIH HHS; P01 CA115675 United States CA NCI NIH HHS; R24 CA083084 United States CA NCI NIH HHS
المشرفين على المادة: 0 (Nitroimidazoles)
0 (Radiopharmaceuticals)
082285VIDF (fluoromisonidazole)
46JO4D76R2 (pimonidazole)
8FE7LTN8XE (Misonidazole)
تواريخ الأحداث: Date Created: 20090227 Date Completed: 20090512 Latest Revision: 20240531
رمز التحديث: 20240531
مُعرف محوري في PubMed: PMC2647727
DOI: 10.1593/neo.81360
PMID: 19242606
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-5586
DOI:10.1593/neo.81360