دورية أكاديمية
[Effects of gamma linolenic acid on atherosclerosis induced by cholesterol-rich diet in rats].
| العنوان: | [Effects of gamma linolenic acid on atherosclerosis induced by cholesterol-rich diet in rats]. |
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| المؤلفون: | Shi LM; School of Life Science, Nanjing University, Nanjing 210093, China., Ge HT, Kong XQ, Cai YF, Li PF, Liu ZL, Kong LD |
| المصدر: | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2008 Dec; Vol. 33 (23), pp. 2808-12. |
| نوع المنشور: | English Abstract; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Country of Publication: China NLM ID: 8913656 Publication Model: Print Cited Medium: Print ISSN: 1001-5302 (Print) Linking ISSN: 10015302 NLM ISO Abbreviation: Zhongguo Zhong Yao Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Beijing : Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Original Publication: [Beijing] : Zhongguo yao xue hui : [Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo, 1989- |
| مواضيع طبية MeSH: | Atherosclerosis/*drug therapy , Cholesterol/*metabolism, Animals ; Atherosclerosis/blood ; Atherosclerosis/metabolism ; Diet, Atherogenic ; Lipids/blood ; Male ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; gamma-Linolenic Acid |
| مستخلص: | Objective: To study the effect of gamma linolenic acid (GLA) on atherogenesis in rats. Method: Sixty healthy male rats were randomly divided into 6 groups: normal contro 1, fed by normal feed; atherogenesis mode 1, fed by high lipid diet; positive control group 0.9 mg x kg(-1) x d(-1) of lovastatin and group IV 250 mg x kg(-1) x d(-1) duoxikang; high dose of 375 mg x kg(-1) x d(-1) GLA; low dose of 187.5 mg x kg(-1) x d(-1) GLA. After the model group received atherogenic diet for six weeks, serum triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were detected by enzyme method to confirm the formation of atherogenic. After fed for another five weeks, morphologic atherosclerosis of aorta in rats was observed by HE staining methods. The blood samples were collected and serum TC, TG, HDL-C, LDL-C, T-AOC, HL, LPL, NO, NOS, MDA and GSH were determined. Result: GLA attenuated the formation of atherosclerotic plaques, inhibited the level of serum TC, TG, MDA, OX-LDL, NO, NOS, HL, LPL and LDL-C and increased the level of T-AOC. Conclusion: GLA might significantly attenuate the development of atherosclerosis in rats fed with high lipid diet through improving the antioxidation capacity of the body. |
| المشرفين على المادة: | 0 (Lipids) 78YC2MAX4O (gamma-Linolenic Acid) 97C5T2UQ7J (Cholesterol) |
| تواريخ الأحداث: | Date Created: 20090306 Date Completed: 20090513 Latest Revision: 20131121 |
| رمز التحديث: | 20231215 |
| PMID: | 19260318 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1001-5302 |
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