دورية أكاديمية
[Association of NAT2 polymorphism with risks to develop psoriasis and various dermatological diseases in Moscow population].
العنوان: | [Association of NAT2 polymorphism with risks to develop psoriasis and various dermatological diseases in Moscow population]. |
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المؤلفون: | Kozhekbaeva ZhM, Gra OA, Fadeev VS, Goldenkova-Pavlova IV, Korsunskaia IM, Bruskin SA, Agafonova EE, Piruzian AL, Surzhikov SA, Nasedkina TV |
المصدر: | Molekuliarnaia biologiia [Mol Biol (Mosk)] 2009 Jan-Feb; Vol. 43 (1), pp. 62-76. |
نوع المنشور: | English Abstract; Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | Russian |
بيانات الدورية: | Publisher: Izdatelstvo Nauka Country of Publication: Russia (Federation) NLM ID: 0105454 Publication Model: Print Cited Medium: Print ISSN: 0026-8984 (Print) Linking ISSN: 00268984 NLM ISO Abbreviation: Mol Biol (Mosk) Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Moskva : Izdatelstvo Nauka |
مواضيع طبية MeSH: | Polymorphism, Single Nucleotide*, Arylamine N-Acetyltransferase/*genetics , Psoriasis/*genetics, Adult ; Alcoholic Beverages/adverse effects ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Moscow ; Psoriasis/epidemiology ; Risk Factors ; Smoking/adverse effects ; Smoking/epidemiology |
مستخلص: | Ruacetyltransferase 2 (NAT2) is one of key enzymes of the second phase of biotransformation that metabolize genotoxic compounds such as carcinogens and mutagens in different types of cells. There is a correlation between the decreasing activity of NAT2 gene product and the sensitivity to harmful environmental factors that increase the risk of occurrence of different multifactorial diseases, including dermatological ones like psoriasis. We developed the NAT2-biochip for 17 SNPs. The biochip was been tested on 279 clinical DNA samples from 180 patients with psoriasis and 99 healthy individuals, residents of Moscow. We found only six SNPs that were significant for European populations (282C > T, 341T > C, 481C > T, 590G > A, 803A > G and 857G > A). The analysis in psoriasis group did not show any genotype association. The increase in frequency of a slow acetylation phenotype in group of patients with type II psoriasis and in group of patients with normosthenic constitution, in comparison with control group (OR = 1.76,p = 0.177 and OR = 2.07,p = 0.050, respectively) has been revealed. The results for patients smoking one or more pack of cigarettes per day, and daily alcohol drinking in comparison with the control showed an increase in frequency for the genotype 341C/C, 481T/T, 803G/G (OR = 7.42, p = 0.008 and OR = 106.11, p = 0.003, respectively). We also found an increase of frequency of genotype 341T/T, 481C/C, 590A/-, 803A/A in patients with side reactions to medical products comparing with group of healthy donors (OR = 2.05, p = 0.099). Thus, the present data show that the certain NAT2 genotypes and some styles of life can be considered as risk factors of psoriasis development in this muscovite population. |
المشرفين على المادة: | EC 2.3.1.5 (Arylamine N-Acetyltransferase) EC 2.3.1.5 (NAT2 protein, human) |
تواريخ الأحداث: | Date Created: 20090402 Date Completed: 20090428 Latest Revision: 20100908 |
رمز التحديث: | 20221213 |
PMID: | 19334527 |
قاعدة البيانات: | MEDLINE |
تدمد: | 0026-8984 |
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