دورية أكاديمية
Evaluation of nephrolithiasis in autosomal dominant polycystic kidney disease patients.
| العنوان: | Evaluation of nephrolithiasis in autosomal dominant polycystic kidney disease patients. |
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| المؤلفون: | Nishiura JL; Nephrology Division, Universidade Federal de São Paulo, São Paulo, Brazil., Neves RF, Eloi SR, Cintra SM, Ajzen SA, Heilberg IP |
| المصدر: | Clinical journal of the American Society of Nephrology : CJASN [Clin J Am Soc Nephrol] 2009 Apr; Vol. 4 (4), pp. 838-44. Date of Electronic Publication: 2009 Apr 01. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wolters Kluwer Health Country of Publication: United States NLM ID: 101271570 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1555-905X (Electronic) Linking ISSN: 15559041 NLM ISO Abbreviation: Clin J Am Soc Nephrol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : Hagerstown, MD : Wolters Kluwer Health Original Publication: Washington, D.C. : American Society of Nephrology, c2005- |
| مواضيع طبية MeSH: | Kidney/*pathology , Nephrolithiasis/*diagnosis , Polycystic Kidney, Autosomal Dominant/*complications, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Biomarkers/urine ; Blood Chemical Analysis ; Female ; Humans ; Kidney/diagnostic imaging ; Logistic Models ; Male ; Middle Aged ; Nephrolithiasis/blood ; Nephrolithiasis/etiology ; Nephrolithiasis/pathology ; Nephrolithiasis/urine ; Organ Size ; Polycystic Kidney, Autosomal Dominant/blood ; Polycystic Kidney, Autosomal Dominant/pathology ; Polycystic Kidney, Autosomal Dominant/urine ; Predictive Value of Tests ; Risk Assessment ; Risk Factors ; Tomography, Spiral Computed ; Ultrasonography ; Urinalysis ; Young Adult |
| مستخلص: | Background and Objectives: Nephrolithiasis (LIT) is more prevalent in patients with autosomal dominant polycystic kidney disease (ADPKD) than in the general population. Renal ultrasonography may underdetect renal stones because of difficulties imposed by parenchymal and/or cyst wall calcifications. Design, Setting, Participants, & Measurements: A total of 125 patients with ADPKD underwent ultrasonography and unenhanced computed tomography (CT) scan, routine blood chemistry, and spot and 24-h urine collections. Results: CT scan detected calculi in 32 patients, including 20 whose previous ultrasonography revealed no calculi. The percentage of hypocitraturia was high but not statistically different between patients with ADPKD+LIT or ADPKD. Hyperuricosuria and distal renal tubular acidosis were less prevalent but also did not differ between groups, whereas hyperoxaluria was significantly higher in the former. Hypercalciuria was not detected. Renal volume was significantly higher in patients with ADPKD+LIT versus ADPKD, and a stepwise multivariate logistic regression analysis showed that a renal volume >or=500 ml was a significant predictor of LIT in patients with ADPKD and normal renal function, after adjustments for age and hypertension. Conclusions: CT scan was better than ultrasonography to detect LIT in patients with ADPKD. Larger kidneys from patients with ADPKD were more prone to develop stones, irrespective of the presence of metabolic disturbances. |
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| المشرفين على المادة: | 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20090403 Date Completed: 20090608 Latest Revision: 20211020 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC2666433 |
| DOI: | 10.2215/CJN.03100608 |
| PMID: | 19339428 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1555-905X |
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| DOI: | 10.2215/CJN.03100608 |