دورية أكاديمية
Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled clinical study.
| العنوان: | Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled clinical study. |
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| المؤلفون: | Ruff KJ; ESM Technologies, LLC, 2213 Missouri Street, Carthage, MO 64836, USA. kruff@esmingredients.com, Winkler A, Jackson RW, DeVore DP, Ritz BW |
| المصدر: | Clinical rheumatology [Clin Rheumatol] 2009 Aug; Vol. 28 (8), pp. 907-14. Date of Electronic Publication: 2009 Apr 02. |
| نوع المنشور: | Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Germany NLM ID: 8211469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1434-9949 (Electronic) Linking ISSN: 07703198 NLM ISO Abbreviation: Clin Rheumatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2008->: Heidelberg : Springer Original Publication: Brussels : Acta Medica Belgica, [1982- |
| مواضيع طبية MeSH: | Dietary Supplements* , Eggs*, Osteoarthritis, Knee/*drug therapy , Pain/*drug therapy, Double-Blind Method ; Egg Proteins/administration & dosage ; Glycosaminoglycans/administration & dosage ; Humans ; Severity of Illness Index |
| مستخلص: | Natural Eggshell Membrane (NEM(R)) is a new novel dietary supplement that contains naturally occurring glycosaminoglycans and proteins essential for maintaining healthy articular cartilage and the surrounding synovium. The randomized, multicenter, double-blind, placebo-controlled Osteoarthritis Pain Treatment Incorporating NEM(R) clinical study was conducted to evaluate the efficacy and safety of NEM(R) as a treatment for pain and stiffness associated with osteoarthritis of the knee. Sixty-seven patients were randomly assigned to receive either oral NEM(R) 500 mg (n = 34) or placebo (n = 33) daily for 8 weeks. The primary endpoint was the change in overall Western Ontario and McMasters Universities (WOMAC) Osteoarthritis Index as well as pain, stiffness, and function WOMAC subscales measured at 10, 30, and 60 days. The clinical assessment was performed on the intent-to-treat population. Supplementation with NEM(R) produced an absolute rate of response that was statistically significant (up to 26.6%) versus placebo at all time points for both pain and stiffness, but was not significantly improved for function and overall WOMAC scores, although trending toward improvement. Rapid responses were seen for mean pain subscores (15.9% reduction, P = 0.036) and mean stiffness subscores (12.8% reduction, P = 0.024) occurring after only 10 days of supplementation. There were no serious adverse events reported during the study and the treatment was reported to be well tolerated by study participants. Natural Eggshell Membrane (NEM(R)) is an effective and safe option for the treatment of pain and stiffness associated with knee osteoarthritis. Supplementation with NEM(R), 500 mg taken once daily, significantly reduced both joint pain and stiffness compared to placebo at 10, 30, and 60 days. |
| References: | Poult Sci. 2003 Mar;82(3):510-4. (PMID: 12705414) Cochrane Database Syst Rev. 2006 Jan 25;(1):CD004257. (PMID: 16437479) J Rheumatol. 1988 Dec;15(12):1833-40. (PMID: 3068365) N Engl J Med. 2005 Mar 17;352(11):1081-91. (PMID: 15713945) Dev Biol. 1984 Jul;104(1):28-36. (PMID: 6203793) Biochem J. 1962 Feb;82:352-61. (PMID: 13864145) Am J Health Syst Pharm. 2005 Oct 1;62(19):2031-6. (PMID: 16174840) Connect Tissue Res. 1980;8(1):53-5. (PMID: 6450664) Biochim Biophys Acta. 1973 Sep 14;320(2):427-41. (PMID: 4750752) Arch Neurol. 2004 Jul;61(7):1066-70. (PMID: 15262737) Connect Tissue Res. 2001;42(4):255-67. (PMID: 11913770) Arch Intern Med. 2003 Jan 27;163(2):169-78. (PMID: 12546607) Eur J Pain. 2007 Feb;11(2):123-4. (PMID: 17067835) Osteoarthritis Cartilage. 2004 May;12(5):389-99. (PMID: 15094138) BMJ. 2002 Sep 21;325(7365):619. (PMID: 12242171) Matrix Biol. 2000 Sep;19(5):443-53. (PMID: 10980420) Pain. 2006 Mar;121(1-2):1-5. (PMID: 16472919) Arthritis Rheum. 2007 Feb;56(2):555-67. (PMID: 17265490) JAMA. 2002 Jan 2;287(1):64-71. (PMID: 11754710) Arthritis Rheum. 2008 Jan;58(1):26-35. (PMID: 18163497) N Engl J Med. 2005 Mar 17;352(11):1071-80. (PMID: 15713944) Arthritis Res Ther. 2008;10(2):R39. (PMID: 18384679) Arthritis Rheum. 1992 May;35(5):498-502. (PMID: 1575785) Arthritis Res Ther. 2006;8(5):R153. (PMID: 16995929) BMJ. 2005 Mar 19;330(7492):672; author reply 672-3. (PMID: 15775007) N Engl J Med. 2005 Mar 17;352(11):1092-102. (PMID: 15713943) Scand J Rheumatol. 2007 Nov-Dec;36(6):411-7. (PMID: 18092260) N Engl J Med. 2006 Feb 23;354(8):795-808. (PMID: 16495392) Gastrointest Endosc Clin N Am. 1996 Jul;6(3):489-504. (PMID: 8803564) |
| سلسلة جزيئية: | ClinicalTrials.gov NCT00750477 |
| المشرفين على المادة: | 0 (Egg Proteins) 0 (Glycosaminoglycans) |
| تواريخ الأحداث: | Date Created: 20090403 Date Completed: 20091013 Latest Revision: 20240511 |
| رمز التحديث: | 20240511 |
| مُعرف محوري في PubMed: | PMC2711914 |
| DOI: | 10.1007/s10067-009-1173-4 |
| PMID: | 19340512 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1434-9949 |
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| DOI: | 10.1007/s10067-009-1173-4 |