دورية أكاديمية
Antifertility activity of aqueous ethanolic leaf extract of Spondias mombin (Anacardiaceae) in rats.
| العنوان: | Antifertility activity of aqueous ethanolic leaf extract of Spondias mombin (Anacardiaceae) in rats. |
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| المؤلفون: | Uchendu CN; Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria. cnuchendu@yahoo.co.uk, Isek T |
| المصدر: | African health sciences [Afr Health Sci] 2008 Sep; Vol. 8 (3), pp. 163-7. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Faculty of Medicine, Makerere University Country of Publication: Uganda NLM ID: 101149451 Publication Model: Print Cited Medium: Internet ISSN: 1729-0503 (Electronic) Linking ISSN: 16806905 NLM ISO Abbreviation: Afr Health Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kampala, Uganda : Faculty of Medicine, Makerere University, [2001- |
| مواضيع طبية MeSH: | Abortifacient Agents/*pharmacology , Anacardiaceae/*chemistry , Infertility, Female/*chemically induced , Infertility, Male/*chemically induced , Plant Extracts/*pharmacology , Reproduction/*drug effects, Analysis of Variance ; Animal Husbandry ; Animals ; Embryo Implantation/drug effects ; Female ; Goats ; Male ; Nigeria ; Phytotherapy ; Plant Extracts/analysis ; Plant Extracts/toxicity ; Plant Leaves ; Rats ; Rats, Wistar ; Sexual Maturation/drug effects |
| مستخلص: | Background: Despite the availability of modern (orthodox) medicine, many developing countries, especially in the rural areas, still rely heavily on traditional healers and medicinal plants to meet their primary health care needs and that of their domestic animals. This has been attributed to easy accessibility and low cost of herbal medicine. In Eastern Nigeria, fresh leaves of Spondias mombin is widely used by the natives to aid delivery and to expel the placenta in small ruminants (sheep and goats), especially during difficult labour. Objective: The present study was designed to evaluate the in vivo effects of leaf extracts of S. mombin on reproductive performance of female rats. Methods: Acute toxicity test of the plant extract was carried out in rats of both sexes. The anticonceptive and abortifacient activity of the extract were investigated, including the Fertility Index or embryo score of control and treated animals. The estrogenic activity was determined using ovariectomized rats. Results: The results revealed a relatively non-toxic plant extract. The extract displayed anticonceptive but not abortifacient activity as judged by the number of pregnant animals at the end of the third trimester of pregnancy. The extract did not exhibit any oestrogenic activity. Conclusion: Aqueous ethanol leaf extract of S. mombin has significant anticonceptive activity attributed to a direct action of the extract on the uterus. |
| References: | Am J Obstet Gynecol. 1976 Sep 1;126(1):48-54. (PMID: 961746) J Ethnopharmacol. 1989 Oct;26(3):317-20. (PMID: 2615412) Toxicol Appl Pharmacol. 1990 Jan;102(1):110-6. (PMID: 2296764) J Cardiovasc Pharmacol. 2004 Nov;44 Suppl 1:S248-51. (PMID: 15838292) Biol Reprod. 2001 Sep;65(3):799-804. (PMID: 11514344) J Reprod Fertil. 1987 Sep;81(1):259-67. (PMID: 3668957) |
| المشرفين على المادة: | 0 (Abortifacient Agents) 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20090410 Date Completed: 20090501 Latest Revision: 20211020 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC2583269 |
| PMID: | 19357744 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1729-0503 |
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