دورية أكاديمية
Synthesis and evaluation of 1-(quinoliloxypropyl)-4-aryl piperazines for atypical antipsychotic effect.
| العنوان: | Synthesis and evaluation of 1-(quinoliloxypropyl)-4-aryl piperazines for atypical antipsychotic effect. |
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| المؤلفون: | Bali A; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India. alka.bali@rediffmail.com, Malhotra S, Dhir H, Kumar A, Sharma A |
| المصدر: | Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Jun 01; Vol. 19 (11), pp. 3041-4. Date of Electronic Publication: 2009 Apr 10. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Ltd Original Publication: Oxford ; New York : Pergamon Press, c1991- |
| مواضيع طبية MeSH: | Antipsychotic Agents/*chemical synthesis , Antipsychotic Agents/*pharmacology , Oxyquinoline/*analogs & derivatives , Oxyquinoline/*chemical synthesis , Oxyquinoline/*pharmacology, Animals ; Antipsychotic Agents/chemistry ; Mice ; Oxyquinoline/chemistry ; Schizophrenia/chemically induced ; Schizophrenia/drug therapy ; Stereotyped Behavior/drug effects |
| مستخلص: | A series of 1-(quinoliloxypropyl)-4-aryl-piperazines has been synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced mesh climbing and stereotypic behaviour in mice. The 8-hydroxyquinoline ether derivative 14 has emerged as an important lead compound showing a potential atypical antipsychotic profile. Employing appropriate physicochemical properties, the similarity of the compounds was assessed with respect to some atypical antipsychotic drugs as clozapine, ketanserine, ziprasidone and risperidone. |
| المشرفين على المادة: | 0 (Antipsychotic Agents) 5UTX5635HP (Oxyquinoline) |
| تواريخ الأحداث: | Date Created: 20090429 Date Completed: 20090717 Latest Revision: 20131121 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.bmcl.2009.04.019 |
| PMID: | 19398330 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1464-3405 |
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| DOI: | 10.1016/j.bmcl.2009.04.019 |