دورية أكاديمية
Prospective evaluation of acute and chronic renal function in children following matched related donor hematopoietic stem cell transplantation.
| العنوان: | Prospective evaluation of acute and chronic renal function in children following matched related donor hematopoietic stem cell transplantation. |
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| المؤلفون: | Ileri T; Department of Pediatric Hematology, Ankara University School of Medicine, Ankara, Turkey. taliaileri@yahoo.com, Ertem M, Ozcakar ZB, Ince EU, Biyikli Z, Uysal Z, Ekim M, Yalcinkaya F |
| المصدر: | Pediatric transplantation [Pediatr Transplant] 2010 Feb; Vol. 14 (1), pp. 138-44. Date of Electronic Publication: 2009 Apr 06. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9802574 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-3046 (Electronic) Linking ISSN: 13973142 NLM ISO Abbreviation: Pediatr Transplant Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Copenhagen ; Malden, MA : Munksgaard, c1997- |
| مواضيع طبية MeSH: | Acute Kidney Injury/*etiology , Glomerular Filtration Rate/*physiology , Hematopoietic Stem Cell Transplantation/*adverse effects , Kidney Failure, Chronic/*etiology, Acute Kidney Injury/blood ; Acute Kidney Injury/physiopathology ; Adolescent ; Child ; Child, Preschool ; Creatinine/blood ; Female ; Follow-Up Studies ; Humans ; Infant ; Kidney/diagnostic imaging ; Kidney/physiopathology ; Kidney Failure, Chronic/blood ; Kidney Failure, Chronic/physiopathology ; Male ; Prognosis ; Prospective Studies ; Risk Factors ; Transplantation, Homologous ; Ultrasonography |
| مستخلص: | Acute and chronic renal impairment are important complications after HSCT. A prospective study was conducted to investigate the glomerular renal function in children who received allogeneic HSCT from matched related donors. Non-radiation conditioning regimens were used in all but one patient. CrCl and serial measurements of serum creatinine were evaluated prior to HSCT, within the first 100 days and one yr after. AKI was defined as at least a 1.5-fold rise in pre-HSCT serum creatinine within the first 100 days and classified as grade 1 to 3 according to the new definition criteria proposed by "AKI Network." Fifty-seven patients were enrolled in the study and 24 patients (42%) had AKI. CsA, amphotericin B, and SOS were found as risk factors for AKI. One yr after HSCT five patients (10%) had CKD and none of them required dialysis. None of the parameters were found as a predictor for CKD. We conclude that AKI is an important complication of HSCT. Careful monitoring of renal function, minimizing the use of nephrotoxic medication, prophylaxis, and effective treatment of SOS might be effective preventive measures to decrease the incidence of AKI. ((c) 2009 John Wiley & Sons A/S.) |
| المشرفين على المادة: | AYI8EX34EU (Creatinine) |
| تواريخ الأحداث: | Date Created: 20090506 Date Completed: 20100406 Latest Revision: 20161125 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1111/j.1399-3046.2009.01182.x |
| PMID: | 19413721 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1399-3046 |
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| DOI: | 10.1111/j.1399-3046.2009.01182.x |