دورية أكاديمية
Transanal endoscopic microsurgery versus total mesorectal excision of T1 rectal adenocarcinomas with curative intention.
| العنوان: | Transanal endoscopic microsurgery versus total mesorectal excision of T1 rectal adenocarcinomas with curative intention. |
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| المؤلفون: | De Graaf EJ; Department of General Surgery, IJsselland Hospital, PO Box 690, 2900 AR, Capelle aan den IJssel, The Netherlands. edgraaf@ysl.nl, Doornebosch PG, Tollenaar RA, Meershoek-Klein Kranenbarg E, de Boer AC, Bekkering FC, van de Velde CJ |
| المصدر: | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2009 Dec; Vol. 35 (12), pp. 1280-5. Date of Electronic Publication: 2009 May 31. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 8504356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2157 (Electronic) Linking ISSN: 07487983 NLM ISO Abbreviation: Eur J Surg Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: London ; New York : Academic Press, [1985- |
| مواضيع طبية MeSH: | Adenocarcinoma/*surgery , Endoscopy, Digestive System/*methods , Microsurgery/*methods , Rectal Neoplasms/*surgery, Adenocarcinoma/pathology ; Adult ; Aged ; Aged, 80 and over ; Blood Loss, Surgical/statistics & numerical data ; Chi-Square Distribution ; Female ; Humans ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Postoperative Complications ; Proportional Hazards Models ; Prospective Studies ; Rectal Neoplasms/pathology ; Statistics, Nonparametric ; Surgical Stomas/statistics & numerical data ; Survival Rate ; Treatment Outcome |
| مستخلص: | Purpose: After total mesorectal excision (TME) for rectal cancer, pathology is standardized with margin status as a predictor for recurrence. This has yet to be implemented after transanal endoscopic microsurgery (TEM) and was investigated prospectively for T1 rectal adenocarcinomas. Patients and Methods: Eighty patients after TEM were compared to 75 patients after TME. The study protocol included standardized pathology. TEM patients were eligible when excision margins were negative. Results: TEM was safer than TME as reflected by operating time, blood loss, hospital stay, morbidity, re-operation rate and stoma formation (all P<0.001). Mortality after TEM was 0% and after TME 4%. At 5 years after TEM and TME, both overall survival (TEM 75% versus TME 77%, P=0.9) and cancer-specific survival (TEM 90% versus TME 87%, P=0.5) were comparable. Local recurrence rate after TEM was 24% and after TME 0% (HR 79.266, 95% CI, 1.208 to 5202, P<0.0001). Conclusion: For T1 rectal adenocarcinomas TEM is much saver than TME and survival is comparable. After TEM local recurrence rate is substantial, despite negative excision margins. |
| تواريخ الأحداث: | Date Created: 20090603 Date Completed: 20091208 Latest Revision: 20220409 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.ejso.2009.05.001 |
| PMID: | 19487099 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-2157 |
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| DOI: | 10.1016/j.ejso.2009.05.001 |