دورية أكاديمية
Clinical criteria as predictive factors of response to primary hormone therapy in locally advanced breast cancer.
| العنوان: | Clinical criteria as predictive factors of response to primary hormone therapy in locally advanced breast cancer. |
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| المؤلفون: | Tiezzi DG; Department of Gynecology and Obstetrics, Breast Disease Division, Hospital das Clínicas of Ribeirão Preto School of Medicine, University of São Paulo, São Paulo, Brazil., de Andrade JM, Marana HR, Garieri AP, de Paula Philbert PM |
| المصدر: | The breast journal [Breast J] 2009 Jul-Aug; Vol. 15 (4), pp. 333-8. Date of Electronic Publication: 2009 May 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: United States NLM ID: 9505539 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4741 (Electronic) Linking ISSN: 1075122X NLM ISO Abbreviation: Breast J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : [Hoboken, New Jersey] : [London] : Hindawi Wiley ; Original Publication: Cambridge, MA : Blackwell Science, c1995- |
| مواضيع طبية MeSH: | Antineoplastic Agents, Hormonal/*therapeutic use , Breast Neoplasms/*drug therapy , Carcinoma, Ductal, Breast/*drug therapy, Aged ; Aged, 80 and over ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Carcinoma, Ductal, Breast/mortality ; Carcinoma, Ductal, Breast/pathology ; Disease Progression ; Disease-Free Survival ; Female ; Humans ; Middle Aged ; Neoplasm Staging ; Postmenopause ; Tamoxifen/therapeutic use ; Treatment Outcome |
| مستخلص: | This study investigates the efficacy of clinical criteria in selecting patients for primary tamoxifen therapy. A total of 60 breast cancer patients with large primary tumors and unknown hormonal receptor status were subjected to primary hormone therapy. Inclusion criteria were age over 60 years old or menopausal status for at least 10 years and no clinical evidence of inflammatory disease and fast tumor growth. The objective response rate was 55%. There was a positive correlation between the lack of clinical response and axillary lymph node metastasis (p = 0.009). Patients with objective response had significantly improved disease-free (p = 0.045) and overall (p = 0.0002) survival over those who did not have response to hormonal therapy. In multivariate analysis, the clinical response to therapy was the most powerful prognostic factor. This analysis demonstrates that clinical criteria were very effective predictor of response to neo-adjuvant hormone therapy in large breast tumors for postmenopausal women. Response to therapy is the major prognostic factor in primary tamoxifen-treated breast cancer. |
| المشرفين على المادة: | 0 (Antineoplastic Agents, Hormonal) 094ZI81Y45 (Tamoxifen) |
| تواريخ الأحداث: | Date Created: 20090606 Date Completed: 20091103 Latest Revision: 20131121 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/j.1524-4741.2009.00736.x |
| PMID: | 19496783 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1524-4741 |
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| DOI: | 10.1111/j.1524-4741.2009.00736.x |