دورية أكاديمية
أعرض في EDS

Selective removal of stratum corneum by microdermabrasion to increase skin permeability.

التفاصيل البيبلوغرافية
العنوان: Selective removal of stratum corneum by microdermabrasion to increase skin permeability.
المؤلفون: Gill HS; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0100, USA., Andrews SN, Sakthivel SK, Fedanov A, Williams IR, Garber DA, Priddy FH, Yellin S, Feinberg MB, Staprans SI, Prausnitz MR
المصدر: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2009 Sep 10; Vol. 38 (2), pp. 95-103. Date of Electronic Publication: 2009 Jun 25.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier Science B.V
Original Publication: Amsterdam ; New York : Elsevier, c1993-
مواضيع طبية MeSH: Permeability* , Skin Absorption*, Adolescent ; Adult ; Aged ; Animals ; Dermabrasion ; Female ; Humans ; Macaca mulatta ; Male ; Microscopy, Electron, Scanning
مستخلص: This study sought to determine if microdermabrasion can selectively remove stratum corneum to increase skin permeability. Although, microdermabrasion has been used for cosmetic treatment of skin for decades, no study has assessed the detailed effects of microdermabrasion conditions on the degree of skin tissue removal. Therefore, we histologically characterized the skin of rhesus macaques and human volunteers after microdermabrasion at different conditions. Using mobile tip microdermabrasion, an increase in the number of treatment passes led to greater tissue removal ranging from minimal effects to extensive damage to deeper layers of the skin. Of note, these data showed for the first time that at moderate microdermabrasion conditions selective yet full-thickness removal of stratum corneum could be achieved with little damage to deeper skin tissues. In the stationary mode of microdermabrasion, selective stratum corneum removal was not observed, but micro-blisters could be seen. Similar tissue removal trends were observed in human volunteers. As proof of concept for drug delivery applications, a model fluorescent drug (fluorescein) was delivered through microdermabraded skin and antibodies were generated against vaccinia virus after its topical application in monkeys. In conclusion, microdermabrasion can selectively remove full-thickness stratum corneum with little damage to deeper tissues and thereby increase skin permeability.
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معلومات مُعتمدة: P30 AI050409 United States AI NIAID NIH HHS; R01 EB006369 United States EB NIBIB NIH HHS; R01 EB006369-01A1 United States EB NIBIB NIH HHS; R01 EB006369 United States EB NIBIB NIH HHS; R01 EB006369-02 United States EB NIBIB NIH HHS; U01 AI074579 United States AI NIAID NIH HHS
تواريخ الأحداث: Date Created: 20090630 Date Completed: 20091109 Latest Revision: 20211020
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC2731013
DOI: 10.1016/j.ejps.2009.06.004
PMID: 19559791
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0720
DOI:10.1016/j.ejps.2009.06.004