دورية أكاديمية
أعرض في EDS

Novel fatty acid desaturase 3 (FADS3) transcripts generated by alternative splicing.

التفاصيل البيبلوغرافية
العنوان: Novel fatty acid desaturase 3 (FADS3) transcripts generated by alternative splicing.
المؤلفون: Park WJ; Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA. wp48@cornell.edu, Kothapalli KS, Reardon HT, Kim LY, Brenna JT
المصدر: Gene [Gene] 2009 Oct 01; Vol. 446 (1), pp. 28-34. Date of Electronic Publication: 2009 Jun 30.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 7706761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0038 (Electronic) Linking ISSN: 03781119 NLM ISO Abbreviation: Gene Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam, Elsevier/North-Holland, 1976-
مواضيع طبية MeSH: Alternative Splicing*, Fatty Acid Desaturases/*genetics , Papio/*genetics, Amino Acid Sequence ; Animals ; Animals, Newborn ; Cell Line ; Conserved Sequence ; Delta-5 Fatty Acid Desaturase ; Female ; Humans ; Isoenzymes/genetics ; Male ; Molecular Sequence Data ; Papio/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Sequence Homology, Amino Acid ; Species Specificity ; Tissue Distribution
مستخلص: Fatty acid desaturase 1 and 2 (FADS1 and FADS2) code for the key desaturase enzymes involved in the biosynthesis of long chain polyunsaturated fatty acids in mammals. FADS3 shares close sequence homology to FADS1 and FADS2 but the function of its gene product remains unknown. Alternative transcripts (AT) generated by alternative splicing (AS) are increasingly recognized as an important mechanism enabling a single gene to code for multiple gene products. We report the first AT of a FADS gene, FADS3, generated by AS. Aided by ORF Finder, we identified putative coding regions of eight AT for FADS3 with 1.34 kb (classical splicing), 1.14 (AT1), 0.77 (AT2), 1.25 (AT3), 0.51 (AT4), 0.74 (AT6), and 1.11 (AT7). In addition we identified a 0.51 kb length transcript (AT5) that has a termination codon within intron 8-9. The expression of each AT was analyzed in baboon neonate tissues and in differentiated and undifferentiated human SK-N-SH neuroblastoma cells. FADS3 AT are expressed in 12 neonate baboon tissues and showed reciprocal increases and decreases in expression changes in response to human neuronal cell differentiation. FADS3 AT, conserved in primates and under metabolic control in human cells, are a putative mediator of LCPUFA biosynthesis and/or regulation.
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معلومات مُعتمدة: R01 GM071534 United States GM NIGMS NIH HHS; R01 GM071534-04 United States GM NIGMS NIH HHS; T32 HD052471 United States HD NICHD NIH HHS; GM071534 United States GM NIGMS NIH HHS
المشرفين على المادة: 0 (Delta-5 Fatty Acid Desaturase)
0 (Isoenzymes)
0 (RNA, Messenger)
EC 1.14.19.- (Fatty Acid Desaturases)
EC 1.14.19.3 (FADS1 protein, human)
تواريخ الأحداث: Date Created: 20090704 Date Completed: 20090831 Latest Revision: 20211203
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC2740906
DOI: 10.1016/j.gene.2009.06.016
PMID: 19573581
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0038
DOI:10.1016/j.gene.2009.06.016