دورية أكاديمية
Performance of an immunoassay at detecting recent infection among reported HIV diagnoses.
| العنوان: | Performance of an immunoassay at detecting recent infection among reported HIV diagnoses. |
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| المؤلفون: | Le Vu S; Department of Infectious Diseases, HIV/AIDS-STI-HCV Unit, Institut de veille sanitaire (French Institute for Public Health Surveillance, InVS), Saint-Maurice, France. s.levu@invs.sante.fr, Meyer L, Cazein F, Pillonel J, Semaille C, Barin F, Desenclos JC |
| المصدر: | AIDS (London, England) [AIDS] 2009 Aug 24; Vol. 23 (13), pp. 1773-9. |
| نوع المنشور: | Evaluation Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8710219 Publication Model: Print Cited Medium: Internet ISSN: 1473-5571 (Electronic) Linking ISSN: 02699370 NLM ISO Abbreviation: AIDS Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1998- : London, England : Lippincott Williams & Wilkins Original Publication: London : Gower Academic Journals, c1987- |
| مواضيع طبية MeSH: | HIV-1*, HIV Infections/*diagnosis, Africa South of the Sahara/ethnology ; Disease Notification ; Epidemiologic Methods ; France/epidemiology ; HIV Infections/epidemiology ; Humans ; Immunoenzyme Techniques/methods ; Time Factors |
| مستخلص: | Introduction: An enzyme immunoassay to detect recent HIV-1 infection (EIA-RI) of less than 6 months is routinely performed on diagnoses reported to the National HIV case surveillance in France. We assessed the performance of the EIA-RI infection on this country population scale by measuring its agreement with other indicators of time since infection that were obtained through clinical, biological or testing history recorded on the surveillance reporting form. Methods: We used data from the National HIV case surveillance from its debut in March 2003 to June 2007. Infection within 6 months was defined as a negative test reported within 6 months prior to diagnosis. We further ascertained this definition by adding information about of a symptomatic primary infection or biological evidence of recent seroconversion. Infection established for more than 6 months was defined when a positive test had occurred more than 6 months prior to the reported diagnosis. Results: Time since infection could be ascertained in 6782 of 15, 331 (44.2%) HIV diagnoses. Assay sensitivity and specificity were 73.8 and 83.7%, respectively. Among the 1940 cases originating from Sub-Saharan Africa, sensitivity and specificity were 54.1 and 90.8%, respectively. Discussion: Assessment of the performance of the EIA-RI on a large and heterogeneous population revealed two major findings--significant discrepancies in timing from infection near the 180-day cutoff, and a performance that depends on the geographic origin of patients. This has implications for estimating the assay window period and in the perspective of incidence estimation from HIV case surveillance. |
| تواريخ الأحداث: | Date Created: 20090714 Date Completed: 20091214 Latest Revision: 20191210 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1097/QAD.0b013e32832d8754 |
| PMID: | 19593080 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1473-5571 |
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| DOI: | 10.1097/QAD.0b013e32832d8754 |