دورية أكاديمية
Impact of surgical staging in locally advanced cervical cancer and subsequent chemotherapy.
| العنوان: | Impact of surgical staging in locally advanced cervical cancer and subsequent chemotherapy. |
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| المؤلفون: | Marana HR; Oncology Section, Department of Gynecology and Obstetrics, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil. marana@keynet.com.br, de Andrade JM, Dos Reis FJ, Tiezzi DG, Zola FE, Clagnan WS, Garieri AP |
| المصدر: | Journal of surgical oncology [J Surg Oncol] 2009 Nov 01; Vol. 100 (6), pp. 505-10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0222643 Publication Model: Print Cited Medium: Internet ISSN: 1096-9098 (Electronic) Linking ISSN: 00224790 NLM ISO Abbreviation: J Surg Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005-> : Hoboken, NJ : Wiley-Liss Original Publication: New York, Plenum. |
| مواضيع طبية MeSH: | Carcinoma/*mortality , Carcinoma/*pathology , Neoplasm Staging/*methods , Uterine Cervical Neoplasms/*mortality , Uterine Cervical Neoplasms/*pathology, Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma/therapy ; Case-Control Studies ; Cisplatin/administration & dosage ; Cohort Studies ; Combined Modality Therapy ; Disease-Free Survival ; Female ; Fluorouracil/administration & dosage ; Humans ; Lymph Node Excision ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Middle Aged ; Uterine Cervical Neoplasms/therapy |
| مستخلص: | Background: Surgical staging (SS) is the gold standard for determination of the true extent of a patient's disease and is an important prognostic factor in cervical cancer. We investigated whether lymph node dissection (LND) prior to chemotherapy (CT) followed by radical surgery (RS) could modified overall (OS) and disease-free survival (DFS). Methods: We performed a cohort analysis of 98 patients with cervical carcinoma. The experimental group consisted of 36 patients who underwent SS followed by neoadjuvant chemotherapy, and then by RS (objective response) or chemo-radiation therapy (with or without subsequent surgery when not possible). The control group consisted of 62 similarly treated patients without pretreatment SS. The value of this procedure as a diagnostic tool in defining the extent of disease was evaluated. Furthermore, LND/CT-associated treatment complications and the impacts on OS and DFS were also evaluated. Results: Fourteen (38.9%) patients had pelvic LN metastases and three (8.3%) patients had pelvic and para-aortic LN metastases. The 39-month OS and DFS rates for the current study were 80.6% for the staged group and 52% for non-staged treatment (P < 0.001). Conclusion: SS in cervical cancer is a feasible and safe pretreatment procedure, and when associated with CT, it improves OS and DFS. |
| المشرفين على المادة: | Q20Q21Q62J (Cisplatin) U3P01618RT (Fluorouracil) |
| تواريخ الأحداث: | Date Created: 20090805 Date Completed: 20091113 Latest Revision: 20131121 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1002/jso.21360 |
| PMID: | 19653248 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1096-9098 |
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| DOI: | 10.1002/jso.21360 |