التفاصيل البيبلوغرافية
| العنوان: |
Clonal diversity of M. tuberculosis isolated in a sea port city in Brazil. |
| المؤلفون: |
Scholante Silva AB; Universidade Federal do Rio Grande, FURG, Brazil. absholante@yahoo.com.br, Von Groll A, Félix C, Conceição FR, Spies FS, Scaini CJ, Rossetti ML, Borsuk S, Dellagostin OA, Almeida da Silva PE |
| المصدر: |
Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2009 Nov; Vol. 89 (6), pp. 443-7. Date of Electronic Publication: 2009 Aug 08. |
| نوع المنشور: |
Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 100971555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-281X (Electronic) Linking ISSN: 14729792 NLM ISO Abbreviation: Tuberculosis (Edinb) Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Edinburgh, New York : Churchill Livingstone, c2001- |
| مواضيع طبية MeSH: |
Genetic Variation*, Mycobacterium tuberculosis/*genetics , Tuberculosis, Pulmonary/*genetics, Bacterial Typing Techniques ; Brazil/epidemiology ; DNA, Bacterial/isolation & purification ; Genotype ; Humans ; Mycobacterium tuberculosis/isolation & purification ; Polymerase Chain Reaction ; Reproducibility of Results ; Tuberculosis, Pulmonary/epidemiology |
| مستخلص: |
Genotyping tools have been widely used to study the occurrence of outbreaks and to identify the patterns of transmission of Mycobacterium tuberculosis strains. The clonal diversity of 65 clinical isolates of M. tuberculosis was determined by PCR methods. The Double Repeat Element method (DRE-PCR) and spoligotyping identified 45 and 26 distinct patterns respectively. Among these, LAM (38%) was the most frequent lineage, followed by Haarlem (31%) and T (20%). Five orphan patterns were not present in the SITVIT database. Mycobacterial interspersed repetitive units (MIRU) using 12 loci revealed 46 distinct patterns. MIRU loci 10, 23, 26 and 40 had the highest discriminatory power. The high genetic diversity found among M. tuberculosis isolates in this study suggests a high level of recent TB transmission, indicating an endemic mode of TB transmission and a putative importation of new TB genotypes. In addition, the high diversity among the isolates could indicate early detection of the infection in patients and an efficient rate of cure. |
| المشرفين على المادة: |
0 (DNA, Bacterial) |
| تواريخ الأحداث: |
Date Created: 20090812 Date Completed: 20111122 Latest Revision: 20091120 |
| رمز التحديث: |
20240628 |
| DOI: |
10.1016/j.tube.2009.05.009 |
| PMID: |
19665929 |
| قاعدة البيانات: |
MEDLINE |
Full Text via ClinicalKey 
Full Text Finder