دورية أكاديمية
The origin of malignant malaria.
| العنوان: | The origin of malignant malaria. |
|---|---|
| المؤلفون: | Rich SM; Laboratory of Medical Zoology, Division of Entomology (PSIS), University of Massachusetts, Amherst, MA 01003, USA. smrich@psis.umass.edu, Leendertz FH, Xu G, LeBreton M, Djoko CF, Aminake MN, Takang EE, Diffo JL, Pike BL, Rosenthal BM, Formenty P, Boesch C, Ayala FJ, Wolfe ND |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2009 Sep 01; Vol. 106 (35), pp. 14902-7. Date of Electronic Publication: 2009 Aug 03. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
| مواضيع طبية MeSH: | Phylogeny*, Malaria/*parasitology , Plasmodium/*genetics , Plasmodium falciparum/*genetics, Amino Acid Sequence ; Animals ; Glycoproteins/genetics ; Humans ; Malaria/metabolism ; Malaria/veterinary ; Molecular Sequence Data ; Mutation ; N-Acetylneuraminic Acid/metabolism ; Pan troglodytes/parasitology ; Plasmodium/chemistry ; Plasmodium/metabolism ; Plasmodium falciparum/chemistry ; Plasmodium falciparum/metabolism ; Protozoan Infections, Animal/metabolism ; Protozoan Infections, Animal/parasitology ; Protozoan Proteins/chemistry ; Protozoan Proteins/metabolism ; Sequence Alignment |
| مستخلص: | Plasmodium falciparum, the causative agent of malignant malaria, is among the most severe human infectious diseases. The closest known relative of P. falciparum is a chimpanzee parasite, Plasmodium reichenowi, of which one single isolate was previously known. The co-speciation hypothesis suggests that both parasites evolved separately from a common ancestor over the last 5-7 million years, in parallel with the divergence of their hosts, the hominin and chimpanzee lineages. Genetic analysis of eight new isolates of P. reichenowi, from wild and wild-born captive chimpanzees in Cameroon and Côte d'Ivoire, shows that P. reichenowi is a geographically widespread and genetically diverse chimpanzee parasite. The genetic lineage comprising the totality of global P. falciparum is fully included within the much broader genetic diversity of P. reichenowi. This finding is inconsistent with the co-speciation hypothesis. Phylogenetic analysis indicates that all extant P. falciparum populations originated from P. reichenowi, likely by a single host transfer, which may have occurred as early as 2-3 million years ago, or as recently as 10,000 years ago. The evolutionary history of this relationship may be explained by two critical genetic mutations. First, inactivation of the CMAH gene in the human lineage rendered human ancestors unable to generate the sialic acid Neu5Gc from its precursor Neu5Ac, and likely made humans resistant to P. reichenowi. More recently, mutations in the dominant invasion receptor EBA 175 in the P. falciparum lineage provided the parasite with preference for the overabundant Neu5Ac precursor, accounting for its extreme human pathogenicity. |
| التعليقات: | Comment in: Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14739-40. (PMID: 19717444) |
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| معلومات مُعتمدة: | K01 TW000003 United States TW FIC NIH HHS; DP1 OD000370 United States OD NIH HHS; DP1-OD00370 United States OD NIH HHS; R01 GM060759 United States GM NIGMS NIH HHS; R01GM70077 United States GM NIGMS NIH HHS; R01 GM070077 United States GM NIGMS NIH HHS; R01GM60759 United States GM NIGMS NIH HHS; 5 K01 TW000003-05 United States TW FIC NIH HHS |
| المشرفين على المادة: | 0 (Glycoproteins) 0 (Protozoan Proteins) 0 (circumsporozoite protein, Protozoan) GZP2782OP0 (N-Acetylneuraminic Acid) |
| تواريخ الأحداث: | Date Created: 20090812 Date Completed: 20091106 Latest Revision: 20211020 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC2720412 |
| DOI: | 10.1073/pnas.0907740106 |
| PMID: | 19666593 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1091-6490 |
|---|---|
| DOI: | 10.1073/pnas.0907740106 |