دورية أكاديمية
Constitutive expression of the ileS-2 gene responsible for high-level mupirocin resistance in Staphylococcus aureus.
| العنوان: | Constitutive expression of the ileS-2 gene responsible for high-level mupirocin resistance in Staphylococcus aureus. |
|---|---|
| المؤلفون: | Oliveira NEM; Instituto de Microbiologia Prof. Paulo de Góes, Bloco I, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Cidade Universitária, 21491-590 Rio de Janeiro, RJ, Brazil., Cavalcanti EDC; Instituto de Química, Bloco A, Centro de Tecnologia, Universidade Federal do Rio de Janeiro, Cidade Universitária, 21491-590 Rio de Janeiro, RJ, Brazil., Laport MS; Instituto de Microbiologia Prof. Paulo de Góes, Bloco I, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Cidade Universitária, 21491-590 Rio de Janeiro, RJ, Brazil., Bastos MDCF; Instituto de Microbiologia Prof. Paulo de Góes, Bloco I, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Cidade Universitária, 21491-590 Rio de Janeiro, RJ, Brazil., Giambiagi-deMarval M; Instituto de Microbiologia Prof. Paulo de Góes, Bloco I, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Cidade Universitária, 21491-590 Rio de Janeiro, RJ, Brazil. |
| المصدر: | Journal of medical microbiology [J Med Microbiol] 2009 Dec; Vol. 58 (Pt 12), pp. 1582-1584. Date of Electronic Publication: 2009 Aug 13. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Microbiology Society Country of Publication: England NLM ID: 0224131 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5644 (Electronic) Linking ISSN: 00222615 NLM ISO Abbreviation: J Med Microbiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : London : Microbiology Society Original Publication: 1968-1995: Edinburgh, Livingstone. |
| مواضيع طبية MeSH: | Bacterial Proteins/*metabolism , Drug Resistance, Bacterial/*genetics , Gene Expression Regulation, Bacterial/*physiology , Mupirocin/*pharmacology , Staphylococcus aureus/*drug effects , Staphylococcus aureus/*genetics, Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Microbial Sensitivity Tests ; Up-Regulation |
| مستخلص: | Mupirocin is a topical antimicrobial agent that is used for the treatment of skin and postoperative wound infections, and the prevention of nasal carriage of methicillin-resistant Staphylococcus aureus (MRSA). However, the prevalence of mupirocin resistance in S. aureus, particularly in MRSA, has increased. High-level mupirocin resistance, with MICs >or=512 microg ml(-1), is mediated by the ileS-2 gene, which is located on conjugative plasmids. In the present study, we investigated whether mupirocin influences the expression of the ileS-2 gene responsible for high-level mupirocin resistance, and we present some evidence that this gene is not upregulated but constitutively expressed in S. aureus. |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Bacterial Proteins) D0GX863OA5 (Mupirocin) |
| تواريخ الأحداث: | Date Created: 20090815 Date Completed: 20091201 Latest Revision: 20200406 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1099/jmm.0.013912-0 |
| PMID: | 19679686 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1473-5644 |
|---|---|
| DOI: | 10.1099/jmm.0.013912-0 |