دورية أكاديمية
[Surgical treatment of maxillary osteonecrosis due to bisphosphonates using an Er:YAG (2940 nm) laser. Discussion of 17 clinical cases].
| العنوان: | [Surgical treatment of maxillary osteonecrosis due to bisphosphonates using an Er:YAG (2940 nm) laser. Discussion of 17 clinical cases]. |
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| عنوان ترانسليتريتد: | Traitement chirurgical des ostéonécroses maxillaires sous bisphosphonates à l'aide du laser Er:YAG (2940 nm). Discussion de 17 cas cliniques. |
| المؤلفون: | Vescovi P; Department of ENT/Dental/Ophthalmological and Cervico-Facial Sciences, Università degli Studi di Parma, Via Gramsci 14, 43100 Parma, Italy. paolo.vescovi@unipr.it, Merigo E, Manfredi M, Meleti M, Fornaini C, Bonanini M, Rocca EP, De Moor RJ, Nammour S |
| المصدر: | Revue belge de medecine dentaire [Rev Belge Med Dent (1984)] 2009; Vol. 64 (2), pp. 87-95. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | French |
| بيانات الدورية: | Publisher: Société de médecine dentaire Country of Publication: Belgium NLM ID: 101555375 Publication Model: Print Cited Medium: Print ISSN: 0775-0293 (Print) Linking ISSN: 07750293 NLM ISO Abbreviation: Rev Belge Med Dent (1984) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1992- : Bruxelles : Société de médecine dentaire Original Publication: 1983-1987: Bruxelles : Société royale belge de médecine dentaire |
| مواضيع طبية MeSH: | Laser Therapy*, Bone Density Conservation Agents/*adverse effects , Diphosphonates/*adverse effects , Jaw Diseases/*surgery , Lasers, Solid-State/*therapeutic use , Osteonecrosis/*surgery, Aged ; Aged, 80 and over ; Bone Neoplasms/drug therapy ; Bone Neoplasms/secondary ; Debridement/methods ; Follow-Up Studies ; Humans ; Iatrogenic Disease ; Jaw Diseases/chemically induced ; Mandibular Diseases/chemically induced ; Mandibular Diseases/surgery ; Maxillary Diseases/chemically induced ; Maxillary Diseases/surgery ; Multiple Myeloma/drug therapy ; Osteonecrosis/chemically induced ; Osteoporosis/drug therapy ; Osteotomy/methods ; Wound Healing/physiology |
| مستخلص: | Reports of cases of ONJ are significantly increased during the last five years as a iatrogenic complication of therapy with bisphosphonates (BPT). The aim of this work is to present the advantages of surgery using Er:YAG laser for treatment of ONJ. Er:YAG laser can gradually reach the healthy bone without causing any heating damage of tissues. This device results very versatile and gives the possibility of choose among different surgical techniques depending by the case (e.g.: vaporization or ostectomy). Moreover, different studies have demonstrated the presence of both bactericidal and biomodulating effect on bone and surrounding tissues, with biostimulation of microcirculation and neoangiogenesis. Seventeen sites of ONJ, classified according to the staging system developed by Ruggiero and observed in 12 patients with multiple myeloma (9 patients), bone metastases (2 patients) and osteoporosis (1 patient), were treated with Er:YAG laser (Fidelis Plus, Fotona-Slovenia). Laser device was used in non-contact or near-contact way (VSP, 300 m3 30 Hz, Fluence 60 J/cm2) on 17 sites (4 Stage I and 13 Stage II) on 3 different types of surgery: sequestrectomy + debridement, sequestrectomy + corticotomy and vaporization. For an average follow-up of 9 months (SD +/- 6 months), complete healing of ONJ (Stage 0) was obtained for 13 sites (76.5%) and resolution of symptoms was obtained (Stage 1) for 3 sites (17.5%). For one site at Stage II (6%), recovery was obtained but this result was not maintained over 3 months. Positive results were independent by the anatomical area (mandible or maxilla), primary disease (osteoporosis, multiple myelomas or metastasis) and discontinuation of BPT before surgery. Er:YAG laser (2940 nm), in our experience, represents a valid therapeutic option for ONJ-BP related, especially in early stages of the disease. |
| المشرفين على المادة: | 0 (Bone Density Conservation Agents) 0 (Diphosphonates) |
| تواريخ الأحداث: | Date Created: 20090818 Date Completed: 20090917 Latest Revision: 20110308 |
| رمز التحديث: | 20231215 |
| PMID: | 19681350 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0775-0293 |
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