دورية أكاديمية
Relation of soluble endothelial protein C receptor and cytokines after allogeneic hematopoietic stem cell transplantation.
| العنوان: | Relation of soluble endothelial protein C receptor and cytokines after allogeneic hematopoietic stem cell transplantation. |
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| المؤلفون: | Azik FM; Department of Pediatric Hematology, Ankara University School of Medicine, Ankara, Turkey. mfatihazik@yahoo.com, Ertem M, Ileri T, Ince EU, Uysal Z, Egin Y, Akar N |
| المصدر: | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis [Clin Appl Thromb Hemost] 2011 Feb; Vol. 17 (1), pp. 94-9. Date of Electronic Publication: 2009 Aug 18. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Publications Country of Publication: United States NLM ID: 9508125 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-2723 (Electronic) Linking ISSN: 10760296 NLM ISO Abbreviation: Clin Appl Thromb Hemost Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Thousand Oaks, CA : Sage Publications Original Publication: New York, N.Y. : Raven Press, c1995- |
| مواضيع طبية MeSH: | Hematopoietic Stem Cell Transplantation*, Antigens, CD/*blood , Cytokines/*blood , Receptors, Cell Surface/*blood , Thrombosis/*blood, Adolescent ; Child ; Child, Preschool ; Endothelial Protein C Receptor ; Female ; Hematologic Neoplasms/blood ; Hematologic Neoplasms/therapy ; Humans ; Infant ; Male ; Protein C/analysis ; Thrombosis/etiology ; Transplantation Conditioning ; Transplantation, Homologous |
| مستخلص: | Aim: The objective of this study was to elucidate the effects of tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), interleukin 2 (IL-2), interleukin 6 (IL-6), and interleukin 8 (IL-8) on the expression of soluble endothelial protein C receptor (sEPCR) in the pathogenesis of thrombotic complications after hematopoietic stem cell transplantation (HSCT). Methods: The relationship between plasma concentrations of proinflammatory cytokines (TNF-α, IL-1β, IL-2, IL-6, and IL-8) and sEPCR was evaluated in 32 consecutive allogeneic hematopoietic stem cell-transplanted patients prior to conditioning regimen and randomly once between +5 and +30 days after transplantation and compared these results with 20 healthy controls. Results: Soluble endothelial protein C receptor levels did not indicate any significant difference between pre- and posttransplantation period, and sEPCR levels showed a significantly negative correlation between IL-6 and IL-8 (sEPCR and IL-6, r = -.43, P < .01; sEPCR and IL-8, r = -.57, P < .01). There was no correlation between sEPCR levels and TNF-α, IL-1β, or IL-2 (sEPCR and TNF-α, r = -.13, P > .05; sEPCR and IL-1β, r = -.1, P ≥ .05; sEPCR and IL-2, r = -.07, P > .05). Conclusions: Our results suggest that the production of sEPCR was not affected by allogeneic HSCT. Soluble endothelial protein C receptor did not show any positive correlation between these proinflammatory cytokines (TNF-α, IL-1β, IL-2, IL-6, and IL-8), on the contrary a significantly negative correlation was determined between sEPCR and either IL-6 or IL-8. This negative correlation may be a protective mechanism in the pathway of protein C activation. |
| المشرفين على المادة: | 0 (Antigens, CD) 0 (Cytokines) 0 (Endothelial Protein C Receptor) 0 (PROCR protein, human) 0 (Protein C) 0 (Receptors, Cell Surface) |
| تواريخ الأحداث: | Date Created: 20090820 Date Completed: 20110420 Latest Revision: 20171116 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1177/1076029609343449 |
| PMID: | 19689997 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1938-2723 |
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| DOI: | 10.1177/1076029609343449 |