دورية أكاديمية
Aqueous extract of brazilian green propolis: primary components, evaluation of inflammation and wound healing by using subcutaneous implanted sponges.
العنوان: | Aqueous extract of brazilian green propolis: primary components, evaluation of inflammation and wound healing by using subcutaneous implanted sponges. |
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المؤلفون: | de Moura SA; Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais-UFMG, Belo Horizonte, Brazil., Negri G, Salatino A, Lima LD, Dourado LP, Mendes JB, Andrade SP, Ferreira MA, Cara DC |
المصدر: | Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2011; Vol. 2011, pp. 748283. Date of Electronic Publication: 2011 Jun 08. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Hindawi Pub Country of Publication: United States NLM ID: 101215021 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1741-4288 (Electronic) Linking ISSN: 1741427X NLM ISO Abbreviation: Evid Based Complement Alternat Med Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Publication: 2011- : New York, NY : Hindawi Pub. Original Publication: Oxford, UK : Oxford University Press, c2004- |
مستخلص: | Propolis is a chemically complex resinous bee product which has gained worldwide popularity as a means to improve health condition and prevent diseases. The main constituents of an aqueous extract of a sample of green propolis from Southeast Brazil were shown by high performance liquid chromatography/mass spectroscopy/mass spectroscopy to be mono- and di-O-caffeoylquinic acids; phenylpropanoids known as important constituents of alcohol extracts of green propolis, such as artepillin C and drupanin were also detected in low amounts in the aqueous extract. The anti-inflammatory activity of this extract was evaluated by determination of wound healing parameters. Female Swiss mice were implanted subcutaneously with polyesther-polyurethane sponge discs to induce wound healing responses, and administered orally with green propolis (500 mg kg(-1)). At 4, 7 and 14 days post-implantation, the fibrovascular stroma and deposition of extracellular matrix were evaluated by histopathologic and morphometric analyses. In the propolis-treated group at Days 4 and 7 the inflammatory process in the sponge was reduced in comparison with control. A progressive increase in cell influx and collagen deposition was observed in control and propolis-treated groups during the whole period. However, these effects were attenuated in the propolis-treated group at Days 4 and 7, indicating that key factors of the wound healing process are modulated by propolis constituents. |
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تواريخ الأحداث: | Date Created: 20090820 Date Completed: 20120823 Latest Revision: 20231105 |
رمز التحديث: | 20231105 |
مُعرف محوري في PubMed: | PMC3137525 |
DOI: | 10.1093/ecam/nep112 |
PMID: | 19690045 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1741-4288 |
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DOI: | 10.1093/ecam/nep112 |