دورية أكاديمية
Circadian phase dependent acute toxicity and pharmacokinetics of etidocaine in serum and brain of mice.
| العنوان: | Circadian phase dependent acute toxicity and pharmacokinetics of etidocaine in serum and brain of mice. |
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| المؤلفون: | Bruguerolle B; Medical Pharmacology Laboratory, Faculty of Medicine, Marseille, France., Prat M |
| المصدر: | The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 1990 Mar; Vol. 42 (3), pp. 201-2. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0376363 Publication Model: Print Cited Medium: Print ISSN: 0022-3573 (Print) Linking ISSN: 00223573 NLM ISO Abbreviation: J Pharm Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [Oxford] : Oxford University Press Original Publication: London : Pharmaceutical Society of Great Britain |
| مواضيع طبية MeSH: | Circadian Rhythm*, Acetanilides/*pharmacokinetics , Brain/*metabolism , Etidocaine/*pharmacokinetics, Animals ; Etidocaine/blood ; Etidocaine/toxicity ; Half-Life ; Injections, Intraperitoneal ; Lethal Dose 50 ; Mice |
| مستخلص: | The aim of this study was to investigate the possible influence of the time of administration on etidocaine acute toxicity and kinetics in mice. Different groups of adult male NMRI mice maintained under controlled environmental conditions (lights on 06.00-18.00) were injected at one of the following times: 10.00, 16.00, 19.00, 22.00, 01.00 and 04.00 h with four doses of etidocaine at each time point to establish the acute toxicity (LD 50). To assess chronokinetics, a single 40 mg kg-1 i.p. dose of etidocaine was given to adult male NMRI mice at four fixed times: 10.00, 16.00, 22.00 and 04.00 h. Etidocaine serum levels were determined by GLC. The data showed significant 24 h variations of the Cmax only (highest value = 9.64 +/- 1.31 micrograms mL-1 at 10.00 P less than 0.05; amplitude, (maximum-minimum) mean x 100 = 84%) Vd, (amplitude = 59.7%), alpha and beta phase elimination half-lives (amplitude = 52 and 35%, respectively), clearance (amplitude = 23%) and AUC infinity 0 (amplitude = 22%) were not found to be significantly time dependent. Etidocaine kinetics in brain were determined similarly; a significant temporal variation was found for the elimination half life (amplitude, 161.9%) and AUC (amplitude, 133.2%) but not for Cmax. These data demonstrate a temporal pattern of etidocaine kinetics similar to those reported previously for other local anaesthetic agents, bupivacaine and mepivacaine. The temporal changes in etidocaine induced acute toxicity may result in part from its chronokinetic changes. |
| المشرفين على المادة: | 0 (Acetanilides) I6CQM0F31V (Etidocaine) |
| تواريخ الأحداث: | Date Created: 19900301 Date Completed: 19900918 Latest Revision: 20190710 |
| رمز التحديث: | 20221208 |
| DOI: | 10.1111/j.2042-7158.1990.tb05387.x |
| PMID: | 1974619 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0022-3573 |
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| DOI: | 10.1111/j.2042-7158.1990.tb05387.x |