دورية أكاديمية
Microcoil embolization for ablation of septal hypertrophy in hypertrophic obstructive cardiomyopathy.
| العنوان: | Microcoil embolization for ablation of septal hypertrophy in hypertrophic obstructive cardiomyopathy. |
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| المؤلفون: | Iacob M; Army Center for Cardiovascular Diseases, Bucharest, Romania., Pinte F, Tintoiu I, Cotuna L, Coroescu M, Filip S, Popa A, Cristian G, Goleanu V, Greere V, Moscaliuc I, Neagoe G, Crisan P, Garjeu A, Chiriac L, Bolohan R, Murgu V, Lobont B, Roates J, Hila G, Postolea E |
| المصدر: | EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology [EuroIntervention] 2005 May; Vol. 1 (1), pp. 93-7. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Société Europa édition Country of Publication: France NLM ID: 101251040 Publication Model: Print Cited Medium: Print ISSN: 1774-024X (Print) Linking ISSN: 1774024X NLM ISO Abbreviation: EuroIntervention Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Toulouse : Société Europa édition, c2005- |
| مستخلص: | Background: Percutaneous transcatheter occlusion with ethanol injection of septal arteries is an efficient treatment procedure of hypertrophic obstructive cardiomyopathy (HOCM). The aim of our study is to evaluate the feasibility and efficiency of septal artery embolization with microcoils. Methods: The microcoils were delivered through the guide-wire lumen of a 2mm-diameter coaxial balloon positioned inside the target vessel as distally as possible. One or more 0.018"-straight microcoils (Hilal straight coils, Cook, USA) were used for each target vessel until complete flow obstruction was noted. The intraventricular pressure gradient was measured before, during and after the procedure. Septal branch occlusion was finally documented by coronary angiography. Results: We treated 7 patients (pts) (male: 5 pts; mean age: 48 (10 years). All patients were symptomatic (NYHA class 3 or 4). The target vessels were successfully occluded in all patients, without complications. Moderate pain was recorded during and after the procedure and the CK level increased five- to ten-fold. The pressure gradient diminished during the procedure from 72 +/- 21 mm Hg to 30 +/- 15 mm Hg. The number of coils delivered ranged from 3 to 7 / patient. The embolized septal branches: 1 vessel in 5 patients; 2 vessels in 1 patient; 3 vessels in 1 case. After the procedure the pressure gradient, evaluated by transthoracic echocardiography, was 34 +/- 16 mm Hg and 42 +/- 12 mm Hg at 3 month-follow-up. Clinical improvement was recorded in all patients after the procedure (NYHA class 1 or 2). Temporary pacing was necessary in 3 patients during and immediately after the procedure but no patient needed permanent pacing. Conclusions: Microcoil embolization is an efficient and safe approach for transcatheter ablation of septal hypertrophy in HOCM. This technique induced myocardial necrosis without the toxic effects of alcohol, reducing the risk of complications (permanent pace-maker implantation, ethanol flow to other myocardial regions). |
| تواريخ الأحداث: | Date Created: 20090918 Date Completed: 20121002 Latest Revision: 20140730 |
| رمز التحديث: | 20221213 |
| PMID: | 19758883 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1774-024X |
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