دورية أكاديمية
Cytotoxic diterpenoids from Croton argyrophylloides.
| العنوان: | Cytotoxic diterpenoids from Croton argyrophylloides. |
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| المؤلفون: | Santos HS; Centro de Ciências Exatas e Tecnologia, Universidade Estadual Vale do Acaraú, 62040-370, Sobral, CE, Brazil., Barros FW, Albuquerque MR, Bandeira PN, Pessoa C, Braz-Filho R, Monte FJ, Leal-Cardoso JH, Lemos TL |
| المصدر: | Journal of natural products [J Nat Prod] 2009 Oct; Vol. 72 (10), pp. 1884-7. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cincinnati, American Society of Pharmacognosy. |
| مواضيع طبية MeSH: | Antineoplastic Agents, Phytogenic/*isolation & purification , Antineoplastic Agents, Phytogenic/*pharmacology , Croton/*chemistry , Diterpenes/*isolation & purification , Diterpenes/*pharmacology , Hemolytic Agents/*isolation & purification , Hemolytic Agents/*pharmacology , Plants, Medicinal/*chemistry, Animals ; Antineoplastic Agents, Phytogenic/chemistry ; Apoptosis/drug effects ; Brazil ; Diterpenes/chemistry ; Drug Screening Assays, Antitumor ; Erythrocytes/drug effects ; HL-60 Cells ; Hemolytic Agents/chemistry ; Humans ; Mice ; Molecular Structure |
| مستخلص: | Two new diterpenes, 1 and 2, together with the known ent-15-oxo-kaur-16-en-18-oic acid (3), were isolated from the bark of Croton argyrophylloides. The structural characterization of 1 and 2 was determined on the basis of spectroscopic data interpretation. The cytotoxicity of each compound was evaluated against HL-60 (leukemia), MDAMB-435 (melanoma), SF-295 (glioblastoma), and HCT-8 (colon carcinoma) human tumor cell lines and against human peripheral blood mononuclear cells. The hemolytic potential in mouse erythrocytes was also tested for 1-3. |
| المشرفين على المادة: | 0 (14-epi-hyalic acid) 0 (Antineoplastic Agents, Phytogenic) 0 (Diterpenes) 0 (Hemolytic Agents) 0 (rel-(1R,4aR,5R,8R)-methyl-7-(1-(methoxycarbonyl)vinyl)-5,8-diacetoxy-1,2,3,4a,5,6,7,8,9,10,10a-dodecahydro-1,4a-dimethyl-2-oxophenanthrene-1-carboxylate) |
| تواريخ الأحداث: | Date Created: 20090929 Date Completed: 20091130 Latest Revision: 20091023 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1021/np900250k |
| PMID: | 19780590 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-6025 |
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| DOI: | 10.1021/np900250k |