دورية أكاديمية
أعرض في EDS

Ex vivo expansion of cord blood.

التفاصيل البيبلوغرافية
العنوان: Ex vivo expansion of cord blood.
المؤلفون: Kelly SS; Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030-4009, USA. sskelly@mdanderson.org, Sola CB, de Lima M, Shpall E
المصدر: Bone marrow transplantation [Bone Marrow Transplant] 2009 Nov; Vol. 44 (10), pp. 673-81. Date of Electronic Publication: 2009 Oct 05.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8702459 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5365 (Electronic) Linking ISSN: 02683369 NLM ISO Abbreviation: Bone Marrow Transplant Subsets: MEDLINE
أسماء مطبوعة: Publication: <2003->: London : Nature Publishing Group
Original Publication: Basingstoke, Hampshire : Scientific & Medical Division, Macmillan Press, c1986-
مواضيع طبية MeSH: Cell Proliferation* , Cord Blood Stem Cell Transplantation*, Fetal Blood/*cytology , Hematopoietic Stem Cells/*physiology, Animals ; Clinical Trials as Topic ; Culture Techniques/trends ; Fetal Blood/transplantation ; Hematopoietic Stem Cells/cytology ; Humans ; Treatment Outcome
مستخلص: A marked increase in the utilization of umbilical cord blood (UCB) transplantation has been observed in recent years; however, the use of UCB as a hematopoietic stem cell (HSC) source is limited primarily by the number of progenitor cells contained in the graft. Graft failure, delayed engraftment and profound delay in immune reconstitution lead to significant morbidity and mortality in adults. The lack of cells available for post transplant therapies, such as donor lymphocyte infusions, has also been considered to be a disadvantage of UCB. To improve outcomes and extend applicability of UCB transplantation, one potential solution is ex vivo expansion of UCB. Investigators have used several methods, including liquid suspension culture with various cytokines and expansion factors, co-culture with stromal elements and continuous perfusion systems. Techniques combining ex vivo expanded and unmanipulated UCB are being explored to optimize the initial engraftment kinetics as well as the long-term durability. The optimal expansion conditions are still not known; however, recent studies suggest that expanded UCB is safe. It is hoped that by ex vivo expansion of UCB, a resulting decrease in the morbidity and mortality of UCB transplantation will be observed, and that the availability of additional cells may allow adoptive immunotherapy or gene transfer therapies in the UCB setting.
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معلومات مُعتمدة: P01 CA055164 United States CA NCI NIH HHS
تواريخ الأحداث: Date Created: 20091006 Date Completed: 20100218 Latest Revision: 20220321
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4157906
DOI: 10.1038/bmt.2009.284
PMID: 19802023
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-5365
DOI:10.1038/bmt.2009.284