دورية أكاديمية
The effect of potassium bromate on some haematological parameters of Wistar rats.
| العنوان: | The effect of potassium bromate on some haematological parameters of Wistar rats. |
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| المؤلفون: | Achukwu PU; Department of Medical Laboratory Sciences, Faculty of Health Sciences and Technology, College of Medicine, University of Nigeria, Enugu Campus, and Department of Haematology, Neuropsychiatric Hospital Enugu, Nigeria., Ufelle SA, Ukaejiofo EO, Ejezie FE, Nwachukwu DN, Nwagha UI, Nworie WC, Anyaehie US |
| المصدر: | Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria [Niger J Physiol Sci] 2009 Jun; Vol. 24 (1), pp. 59-61. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Physiological Society of Nigeria Country of Publication: Nigeria NLM ID: 8811109 Publication Model: Print Cited Medium: Print ISSN: 0794-859X (Print) Linking ISSN: 0794859X NLM ISO Abbreviation: Niger J Physiol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Benin City, Nigeria : Physiological Society of Nigeria |
| مواضيع طبية MeSH: | Bromates/*toxicity , Food Additives/*toxicity, Animals ; Blood Platelets/drug effects ; Hematocrit ; Hemoglobins/metabolism ; Leukocyte Count ; Leukocytes/drug effects ; Male ; Platelet Count ; Rats ; Rats, Wistar ; Risk Assessment |
| مستخلص: | Potassium bromate used widely in foods has been associated with various complications in humans. However there is paucity of literature on adverse effects on haematological parameters. Thus we decided to carry out an experimental study to determine the effects of potassium bromate on some blood indices using Wistar rats. Twenty (20) male Wistar rats aged 2-3 months obtained from the department of Veterinary Medicine, University of Nigeria Nsukka were acclimatized for two weeks. They were divided into five groups and fed with graded doses of potassium bromate solution for six weeks. One of the groups served as the control. Pre and post administration blood samples were collected and analyzed the same day using standard methods. The results revealed significant [P<0.05] decrease in the platelet count when compared with the controls. There were no statistically significant differences in the mean cell haemoglobin concentration, haematocrit, and total leukocyte counts between the test and control rats. Potassium bromate is injurious to health if consumed continuously and in high quantity. It has been shown to reduce platelet count in rats, and thus may cause thrombocytopenia in humans. It is therefore imperative to take adequate measures to eliminate the use of potassium bromate in the preparation of food products. |
| المشرفين على المادة: | 0 (Bromates) 0 (Food Additives) 0 (Hemoglobins) 04MB35W6ZA (potassium bromate) |
| تواريخ الأحداث: | Date Created: 20091015 Date Completed: 20101019 Latest Revision: 20191111 |
| رمز التحديث: | 20240628 |
| DOI: | 10.4314/njps.v24i1.46383 |
| PMID: | 19826465 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0794-859X |
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| DOI: | 10.4314/njps.v24i1.46383 |