دورية أكاديمية
[Cardioprotective action of coenzyme Q in conditions of its endogenous synthesis activation in cardiac ischemia-reperfusion in old rats].
| العنوان: | [Cardioprotective action of coenzyme Q in conditions of its endogenous synthesis activation in cardiac ischemia-reperfusion in old rats]. |
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| المؤلفون: | Timoshchuk SV, Vavilova HL, Strutyns'ka NA, Talanov SA, Petukhov DM, Kuchmenko OB, Donchenko HV, Sahach VF |
| المصدر: | Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) [Fiziol Zh (1994)] 2009; Vol. 55 (4), pp. 58-63. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Ukrainian |
| بيانات الدورية: | Publisher: Naukova Dumka Country of Publication: Ukraine NLM ID: 9601541 Publication Model: Print Cited Medium: Print ISSN: 2522-9028 (Print) Linking ISSN: 25229028 NLM ISO Abbreviation: Fiziol Zh (1994) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Kyiv : Naukova Dumka Original Publication: Kyïv : Nauk. dumka, 1994- |
| مواضيع طبية MeSH: | Aging/*metabolism , Myocardial Reperfusion Injury/*prevention & control , Myocardium/*metabolism , Ubiquinone/*biosynthesis, Aging/drug effects ; Aging/pathology ; Animals ; Cardiotonic Agents/pharmacology ; Coronary Circulation/drug effects ; Heart/drug effects ; Heart Function Tests ; In Vitro Techniques ; Male ; Methionine/pharmacology ; Myocardial Reperfusion ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/pathology ; Myocardium/pathology ; Parabens/pharmacology ; Rats ; Rats, Wistar ; Ubiquinone/physiology ; alpha-Tocopherol/pharmacology |
| مستخلص: | The changes of functional state isolated by Lanhendorf old rat hearts with low content of ubiqinone--coenzyme Q (CoQ) under activation of it endogenous synthesis through administration of precursors--4-hydroxybenzoic acid, methionine and modulator vitamin E were studied. The activation of ubiqinone biosynthesis contribute to cardioprotective effect due to reduce the degree of the ischemia-reperfusion injury in old rat heart, namely the restoration of myocardial contractile function and coronary flow as well as decrease the end diastolic pressure and oxygen cost of the heart compared with control group of the animals during ischemia-reperfusion. Thus the results allow to conclude that the activation of KoQ biosynthesis under administration of it precursors has protective effect in the development of the heart postreperfusion damages in aging. |
| المشرفين على المادة: | 0 (Cardiotonic Agents) 0 (Parabens) 1339-63-5 (Ubiquinone) AE28F7PNPL (Methionine) H4N855PNZ1 (alpha-Tocopherol) JG8Z55Y12H (4-hydroxybenzoic acid) |
| تواريخ الأحداث: | Date Created: 20091016 Date Completed: 20100302 Latest Revision: 20141120 |
| رمز التحديث: | 20221213 |
| PMID: | 19827631 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2522-9028 |
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