دورية أكاديمية
[Cytogenetic monitoring acute myeloid leucosis in children].
| العنوان: | [Cytogenetic monitoring acute myeloid leucosis in children]. |
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| المؤلفون: | Fleĭshman EV, Sokova OI, Popa AV, Konstantinova LN, Metel'kova NF, Serebriakova IN, Peregudov DA |
| المصدر: | Vestnik Rossiiskoi akademii meditsinskikh nauk [Vestn Ross Akad Med Nauk] 2009 (9), pp. 28-32. |
| نوع المنشور: | Comparative Study; English Abstract; Journal Article; Multicenter Study |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Pediatr Country of Publication: Russia (Federation) NLM ID: 9215641 Publication Model: Print Cited Medium: Print ISSN: 0869-6047 (Print) Linking ISSN: 08696047 NLM ISO Abbreviation: Vestn Ross Akad Med Nauk Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2016- > : Moskva : Pediatr Original Publication: Moskva : Meditsina, 1992- |
| مواضيع طبية MeSH: | Chromosome Aberrations*, Bone Marrow Cells/*pathology , Leukemia, Myeloid, Acute/*genetics, Adolescent ; Child ; Child, Preschool ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Infant ; Infant, Newborn ; Karyotyping ; Leukemia, Myeloid, Acute/diagnosis ; Male ; Prognosis |
| مستخلص: | Preliminary results of cytogenetic monitoring acute myeloid leukosis (AML) in children are presented. Repeated chromosomal analyses were accomplished in 23 patients that presented with cell clones showing various karyotype abnormalities prior to the onset of therapy. All the patients were treated following identical protocols. Complete hematological remission was achieved in 20 cases. The majority of patients did not have cells with chromosomal abnormalities changes after a 2-4 month follow up. Anomalous metaphases persisted in 6 patients although their occurrence decreased. Five of them poorly responded to therapy whereas simultaneous achievement of morphological and cytogenetic remission ensured more beneficial outcome of the treatment. Results of the study agree with recent reports of delayed reversion to normal karyotype under effect of AML therapy that as a rule predicts an unfavourable prognosis Repeated analysis during stable hematological remission did not reveal cells with karyotype abnormalities in bone marrow with the exception of a single patient who had marrow cells with chromosomal translocation (16:16) up to the 8th month of complete hematological remission. This patient remains under observation (duration of remission is now 15 months). It was shown that the relative amount of cells with abnormal karyotype in bone marrow frequently exceeds that of blast cells (usually before the onset of therapy and sometimes in the beginning of morphological remission). During stable remission, such an excess is an antecedent of relapse. It is concluded that cytogenetic analysis for monitoring AML extends the possibility of detecting leukemia cells. |
| تواريخ الأحداث: | Date Created: 20091016 Date Completed: 20091208 Latest Revision: 20161020 |
| رمز التحديث: | 20231215 |
| PMID: | 19827640 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0869-6047 |
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