دورية أكاديمية
Histiocytosis disorders in Northeast Egypt: epidemiology and survival studies (a 5-year study).
| العنوان: | Histiocytosis disorders in Northeast Egypt: epidemiology and survival studies (a 5-year study). |
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| المؤلفون: | Al-Tonbary YA; Mansoura University Children's Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt. ytonbary@gmail.com, Sarhan MM, Mansour AK, Abdelrazik NM, El-Ashry RA |
| المصدر: | Hematology (Amsterdam, Netherlands) [Hematology] 2009 Oct; Vol. 14 (5), pp. 271-6. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 9708388 Publication Model: Print Cited Medium: Internet ISSN: 1607-8454 (Electronic) Linking ISSN: 10245332 NLM ISO Abbreviation: Hematology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : Abingdon : Taylor & Francis Original Publication: [Amsterdam] : Newark, NJ : Harwood Academic Publishers ; International Publishers Distributor, |
| مواضيع طبية MeSH: | Histiocytosis/*mortality, Age Factors ; Child ; Child, Preschool ; Egypt/epidemiology ; Female ; Giant Cells/pathology ; Giant Cells/physiology ; Histiocytosis/pathology ; Histiocytosis/therapy ; Humans ; Infant ; Langerhans Cells/pathology ; Leukocytes/pathology ; Longitudinal Studies ; Male ; Survival Rate |
| مستخلص: | Histiocytosis disorders include a wide group of disorders characterized by monocytes, macrophages and dendritic cell infiltration of different tissues. There are few clinico-epidemiologic studies of such disease. Our study was designed to look at the clinico-epidemiological features and outcome of patients with histiocytosis disorders in Northeast Egypt. Twenty-seven cases with histiocytosis disorders accrued over a 5-year period were analyzed and classified as having unifocal, multifocal, or multisystem disease. They were 14 males and 13 females. Twenty-two patients representing 81.5% of cases were more than two years of age while 5 patients (18.5%) were less than 2 years. Lymphadenopathy was the commonest presentation (55.55%) followed by bone lesions (44.44%). Involvement was unifocal in 12, multifocal in 10, and multisystem in 5 cases. The histological features were relatively uniform regardless of the clinical severity, and consisted of Langerhans cells, eosinophils, histiocytes, plasma cells, giant cells and fibrosis. The treatment consisted of a combination of surgery, chemotherapy, and/or radiotherapy. Lymphadenopathy was the most common clinical presentation in our locality. Response to treatment was poor in patients with multisystem disease. Patients with age less than 2 years were more likely to have increased risk of morbidity and mortality, due to widespread disease. |
| تواريخ الأحداث: | Date Created: 20091022 Date Completed: 20100107 Latest Revision: 20091021 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1179/102453309X439809 |
| PMID: | 19843382 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1607-8454 |
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| DOI: | 10.1179/102453309X439809 |